Evidence map›Paper›PMID 29507083›Full record

ArticleInfection and immunity2018

Chemotaxis Allows Bacteria To Overcome Host-Generated Reactive Oxygen Species That Constrain Gland Colonization.

Kieran D Collins, Shuai Hu, Helmut Grasberger, John Y Kao, Karen M Ottemann

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. ZnbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. TheJournal of bacteriology · 2026
    Article
  4. Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026
    Review
  5. Review
  6. Chemotactic behaviour ofParasitology · 2025
    Article
  7. Bacterial chemotaxis in human diseases.Trends in microbiology · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kieran D CollinsDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.
Shuai HuDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.
Helmut GrasbergerDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
John Y KaoDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Karen M OttemannDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA Ottemann@ucsc.edu.ORCID 0000-0001-6265-7401
University of California, Santa Cruz · USUniversity of Michigan · US

Funding

Mechanisms of gut epithelial DUOX-mediated intestinal homeostasisR01DK117565 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRASBERGER, HELMUT F, KAO, JOHN Y · 2018 to 2021
$2.0M
Role of Dendritic Cells in H pylori-induced Treg-mediated Host Immune ToleranceR01DK087708 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAO, JOHN Y · 2011 to 2015
$2.0M
The mechanism and biological consequence of ROS chemotaxisR21AI117345 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2015 to 2016
$416k
NIAID NIH HHS R21 AI117345NIDDK NIH HHS R01 DK087708NIDDK NIH HHS R01 DK117565
6 · The paper itself

Abstract

The epithelial layer of the gastrointestinal tract contains invaginations, called glands or crypts, which are colonized by symbiotic and pathogenic microorganisms and may function as designated niches for certain species. Factors that control gland colonization are poorly understood, but bacterial chemotaxis aids occupation of these sites. We report here that a

Indexed as

AnimalsBacterial ProteinsCarrier StateChemotaxisFemaleGastric MucosaGene Expression RegulationGenes, BacterialHelicobacter pyloriHumansMaleMiceMice, KnockoutMutationReactive Oxygen SpeciesBacterial ProteinsReactive Oxygen SpeciesbiogeographychemoreceptorscryptsglandsMCPreactive oxygen speciessignal transductionstomach

Identifiers

PMID29507083
PMCPMC5913845
OpenAlexW2767830642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.