ArticleDiabetes care2018
Obesity Progression Between Young Adulthood and Midlife and Incident Diabetes: A Retrospective Cohort Study of U.S. Adults.
Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05604950 (Sichuan Cancer Hospital & Institute), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sichuan Cancer Hospital & Institute
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.Cardiovascular diabetology · 2020Pooled it
- Enhanced Metabolic Risks in Patients with Obesity and Nutritional Deficiencies in the U.S.: A TriNetX Study.Nutrients · 2026Article
- Weight change across adulthood in relation to ultrasound-defined metabolic dysfunction-associated steatotic liver disease: a population-based study.Journal of global health · 2026Article
- The transition from preclinical to clinical obesity: the importance of a borderline stage.Clinical science (London, England : 1979) · 2026Review
- Association between weight change across adulthood and risk of chronic kidney disease: NHANES 1999-2020.Renal failure · 2025Article
- Association of past obesity and BMI trajectories with cancer mortality: a prospective cohort study.Archives of public health = Archives belges de sante publique · 2025Article
- MASLD, At-Risk MASH and Increased Liver Stiffness Are Associated With Young Adulthood Obesity Without Residual Risk After Losing Obesity.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Obesity in Prediabetic Patients: Management of Metabolic Complications and Strategies for Prevention of Overt Diabetes.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Weight change across adulthood in relation to the risk of COPD.Environmental health and preventive medicine · 2025Article
- Identification of sensitive periods of weight status transition over the lifespan in Chinese population.BMC medicine · 2024Article
- Association between weight change and serum anti-aging protein α-Klotho: a cross-sectional study in middle-aged and older adults.Scientific reports · 2024Article
- Imaging-based body fat distribution and diabetic retinopathy in general US population with diabetes: an NHANES analysis (2003-2006 and 2011-2018).Nutrition & diabetes · 2024Article
- Weight change patterns across adulthood are associated with the risk of osteoarthritis: a population-based study.Aging clinical and experimental research · 2024Article
- BMI Trajectories in Late Middle Age, Genetic Risk, and Incident Diabetes in Older Adults: Evidence From a 26-Year Longitudinal Study.American journal of epidemiology · 2024Article
- Patterns of weight change during adulthood and incidence of nephrolithiasis: a population-based study.International journal of obesity (2005) · 2024Article
- The association between weight change patterns and obesity-related complex multimorbidity: evidence from NHANES.Frontiers in endocrinology · 2024Article
- Association between changes in body composition and progression of liver fibrosis in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2024Article
- Clinical features of early-onset type 2 diabetes and its association with triglyceride glucose-body mass index: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Weight changes from early to middle adulthood and cardiometabolic multimorbidity later in life among middle-aged and older adults: a retrospective cohort study from the NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- Trends in weight change patterns across life course among US adults, 1988-2018: population-based study.BMC public health · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveUnderstanding how changes in weight over the life course shape risk for diabetes is critical for the prevention of diabetes. Using data from the National Health and Nutrition Examination Survey (NHANES), we investigated the association between self-reported weight change from young adulthood to midlife and incident diabetes. RESEARCH DESIGN AND
methodsWe categorized individuals into four weight-change groups: those who remained nonobese (stable nonobese), those who moved from an obese BMI to a nonobese BMI (losing), those who moved from a nonobese BMI to an obese BMI (gaining), and those who remained obese (stable obese). Diabetes status was determined by self-report of a prior diagnosis, and age at diagnosis was used to establish time of diabetes onset. Hazard ratios (HRs) relating weight change to incident diabetes over 10 years of follow-up were calculated using Cox models adjusting for covariates.
resultsThose who were obese and lost weight exhibited a significantly lower risk (HR 0.33; 95% CI 0.14, 0.76) of diabetes compared with those with stable obesity. We also observed lower risk among those who were stable nonobese (HR 0.22; 95% CI 0.18, 0.28) and those in the gaining category (HR 0.70; 95% CI 0.57, 0.87). Further, there was evidence of an increased incidence of diabetes among obese individuals who lost weight compared with individuals who were stable nonobese; however, weight loss was rare, and the association was not statistically significant. If those who were obese had become nonobese during the 10-year period, we estimate that 9.1% (95% CI 5.3, 12.8) of observed diabetes cases could have been averted, and if the population had maintained a normal BMI during the period, 64.2% (95% CI 59.4, 68.3) of cases could have been averted.
conclusionsThe findings from this study underscore the importance of population-level approaches to the prevention and treatment of obesity across the life course of individuals.
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