Evidence map›Paper›PMID 29506577›Full record

ArticleLipids in health and disease2018

Atherogenic index of plasma is a novel and better biomarker associated with obesity: a population-based cross-sectional study in China.

Xiaowei Zhu, Lugang Yu, Hui Zhou, Qinhua Ma, Xiaohua Zhou, Ting Lei, Jiarong Hu, Wenxin Xu, Nengjun Yi, Shufeng Lei

Abstract read
In one paragraph

Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Observational
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaowei ZhuCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
Lugang YuCenter for Disease Control and Prevention of Suzhou Industry Park, Suzhou, Jiangsu, 215021, China.
Hui ZhouCenter for Disease Control and Prevention of Suzhou Industry Park, Suzhou, Jiangsu, 215021, China.
Qinhua MaNo. 3 People's Hospital of Xiang Cheng District, Suzhou, Jiangsu, 215134, China.
Xiaohua ZhouNo. 3 People's Hospital of Xiang Cheng District, Suzhou, Jiangsu, 215134, China.
Ting LeiCenter for Disease Control and Prevention of Suzhou Industry Park, Suzhou, Jiangsu, 215021, China.
Jiarong HuNo. 3 People's Hospital of Xiang Cheng District, Suzhou, Jiangsu, 215134, China.
Wenxin XuNo. 3 People's Hospital of Xiang Cheng District, Suzhou, Jiangsu, 215134, China.
Nengjun YiDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Shufeng LeiCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, 215123, China. leisf@suda.edu.cn.

Funding

National Natural Science Foundation of China 81473046,31271336, 81373010, 81502868, 31401079, 81401343, 81541068Natural Science Foundation of Jiangsu Province BK20130300, BK20150346Project of Preventive Medicine of Jiangsu Province Y2012024
6 · The paper itself

Abstract

backgroundAtherogenic index of plasma (AIP) has been reported to be associated with cardiovascular diseases. However no study has yet systematically evaluated the association between AIP and obesity and its advantage in obesity prediction compared with conventional lipid components.

methodsA total of 6465 participants aged over 30 years were included in this study. Blood lipid components including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured, and AIP was calculated as log

resultsSubjects in the higher quartiles of AIP all had a significantly increased risk of obesity compared with those in the lowest quartile (P for trend< 0.01). AIP showed a stronger association with obesity than the conventional lipid components as the pearson coefficient reached up to 0.372 and the adjusted odds ratio was 5.55. Using AIP rather than HDL-C and TG significantly improved risk prediction for obesity (AUC improvement = 0.011, P = 0.011; Continuous net reclassification index = 29.55%, P < 0.01; Category net reclassification index = 6.06%; Integrated discrimination improvement = 0.68%, P < 0.01).

conclusionsHigher AIP level was positively and strongly associated with obesity. AIP is a novel and better biomarker associated with obesity. Controlling the AIP level would be more helpful for the prevention of obesity.

Indexed as

AgedAtherosclerosisBiomarkersChinaCholesterolCholesterol, HDLCross-Sectional StudiesFemaleHumansLipidsMaleMiddle AgedObesityTriglyceridesBiomarkersCholesterolCholesterol, HDLLipidsTriglyceridesAtherogenic index of plasmaBlood lipid componentsObesity

Identifiers

PMID29506577
PMCPMC5836428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.