ArticleRadiation oncology (London, England)2018
Linac-based VMAT radiosurgery for multiple brain lesions: comparison between a conventional multi-isocenter approach and a new dedicated mono-isocenter technique.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Simultaneous stereotactic radiosurgery of multiple brain metastases using single-isocenter dynamic conformal arc therapy: a prospective monocentric registry trial.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Trial
- Validation of the clinical applicability of knowledge-based planning models in single-isocenter volumetric-modulated arc therapy for multiple brain metastases.Journal of applied clinical medical physics · 2020Trial
- Memory circuit dosimetry in patients with brain metastases treated with Sparing Memory with Advanced Radiosurgery Targeting (SMART) technique.Clinical and translational radiation oncology · 2026Article
- Assessing the role of plan complexity and target geometry through multi-institutional gel based end-to-end QA in multi-focal single isocenter stereotactic radiosurgery.Journal of applied clinical medical physics · 2026Article
- Automatic single-isocenter multiple-target cranial stereotactic treatment plan optimization via planning system scripting.Journal of applied clinical medical physics · 2026Article
- Hybrid geometric and evolutionary optimization framework for radiosurgery planning: isocenter selection and angle optimization for multiple brain metastases.Radiological physics and technology · 2026Article
- Evaluation of the environ SRS immobilization mask system for HyperArc: Dosimetric attenuation, dose calculation accuracy, and clinical setup reproducibility.Journal of applied clinical medical physics · 2026Article
- Evaluation of dosimetric impact and plan robustness of MLC motion and setup errors in SRS for multiple brain metastases.Journal of applied clinical medical physics · 2026Article
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- Article
- Knowledge based automated planning for non-coplanar VMAT stereotactic radiosurgery in ocular malignancies.Journal of applied clinical medical physics · 2026Article
- Dual optimization in single-isocenter radiosurgery for multiple brain metastases: a dosimetric planning study.Frontiers in oncology · 2026Article
- Patient-specific quality assurance for extremely small field sizes using 3D in vivo dosimetry in fractionated stereotactic radiosurgery for brain metastases.Journal of applied clinical medical physics · 2026Article
- Stratified dosimetric comparison between high-definition multileaf collimator-based D2SRS and robotic radiosurgery in the treatment of brain metastases.Journal of applied clinical medical physics · 2025Article
- The feasibility of using coplanar-only VMAT combined with "Treat" function to replace non-coplanar VMAT for SRS of 2 to 6 brain metastases.Quantitative imaging in medicine and surgery · 2025Article
- Feasibility of treatment planning with HyperArc stereotactic radiosurgery methods for ocular tumors.Journal of applied clinical medical physics · 2025Article
- Quality and Dosimetric Accuracy of Linac-Based Single-Isocenter Treatment Plans for Four to Eighteen Brain Metastases.Cancers · 2025Article
- Reporting Clinical Results of EPID-Based Patient-Specific Quality Assurance for Brain Stereotactic Radiosurgery/Radiation Therapy: Demonstrating the Feasibility of Same-Day Stereotactic Radiosurgery via HyperArc Delivery.Advances in radiation oncology · 2025Article
- Evaluation of the system accuracy of frameless stereotactic radiosurgery using a combination of cone beam CT, six degrees of freedom couch, and surface image-guided systems.Journal of applied clinical medical physics · 2025Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLinac-based stereotactic radiosurgery or fractionated stereotactic radiotherapy (SRS/FSRT) of multiple brain lesions using volumetric modulated arc therapy (VMAT) is typically performed by a multiple-isocenter approach, i.e. one isocenter per lesion, which is time-demanding for the need of independent setup verifications of each isocenter. Here, we present our initial experience with a new dedicated mono-isocenter technique with multiple non-coplanar arcs (HyperArc™, Varian Inc.) in terms of a plan comparison with a multiple-isocenter VMAT approach.
methodsFrom August 2017 to October 2017, 20 patients with multiple brain metastases (mean 5, range 2-10) have been treated by HyperArc in 1-3 fractions. The prescribed doses (Dp) were 18-25 Gy in single-fraction, and 21-27 Gy in three-fractions. Planning Target Volume (PTV), defined by a 2 mm isotropic margin from each lesion, had mean dimension of 9.6 cm
resultsSignificant variations in favour of HA plans were computed for both target dose indexes, CI (p < .01) and GI (p < .01). The lower GI in HA plans was the likely cause of the significant reduction in V
conclusionsFor linac-based SRS/FSRT of multiple brain lesions, HyperArc plans assured a higher CI and a lower GI than standard multiple-isocenter VMAT plans. This is consistent with the computed reduction in V
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.