SynthesisThe Australian and New Zealand journal of psychiatry2018
Guidelines on treatment of perinatal depression with antidepressants: An international review.
Synthesis in The Australian and New Zealand journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05046405 (Home-based Transcranial Direct Current Stimulation in Postpartum Depression), which is not on this map. Cited by 62 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home-based Transcranial Direct Current Stimulation in Postpartum Depression: the Feasibility Study and Pilot Study
Who cites it
62 citing papers in PubMed, 6 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Psychiatric Association of Türkiye Mood Disorders Section Depression Treatment Guideline - III: Treatment Approach for Depression Subtypes and Special Groups, Psychotherapies, and Psychosocial Interventions.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Guideline
- Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses.Paediatric drugs · 2023Pooled it
- Clinical practice guidelines with recommendations for peripartum depression: A European systematic review.Acta psychiatrica Scandinavica · 2022Pooled it
- A systematic review of screening for perinatal depression and anxiety in community-based settings.Archives of women's mental health · 2022Pooled it
- Antidepressant treatment for postnatal depression.The Cochrane database of systematic reviews · 2021Pooled it
- Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review.The Journal of clinical psychiatry · 2020Pooled it
- Internet-Based Problem Management Plus Intervention for Antenatal Depression: Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Treatment of Perinatal Depression and Correlates of Treatment Response Among Pregnant Women Living with HIV in Uganda.Maternal and child health journal · 2023Trial
- Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.BMJ open · 2020Trial
- Coupling thin film nanofiltration membrane and photocatalyst for the removal of antidepressant drugs from aqueous solutions.Scientific reports · 2026Article
- Depression and antidepressant treatment in growing up in New Zealand: impact on preterm birth and low birth weight.Archives of women's mental health · 2026Article
- Managing anxiety-related disorders from pregnancy to parenthood.Archives of gynecology and obstetrics · 2026Review
- Knowledge and Confidence in Psychotropic Prescribing, Utilisation of Guidelines and Resources in Managing Perinatal Mental Health in General Practice: An Australian Cross-Sectional Survey.The Australian journal of rural health · 2026Article
- Optimising antidepressant therapy in pregnancy: a perspective on therapeutic drug monitoring and model-informed precision dosing.Frontiers in pharmacology · 2026Article
- First trimester antidepressant use and miscarriage: a population-based cohort study using Clinical Practice Research Datalink GOLD.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Prediction of Maternal and Fetal Exposure to Escitalopram, Sertraline, and Paroxetine by Combining Human Ex Vivo Placenta Perfusion Data and Physiologically Based Pharmacokinetic Modeling.Clinical pharmacokinetics · 2025Article
- Peripartum sertraline impacts maternal neurobehavioral and neurodegenerative mechanisms in pregnant and postpartum mice.Molecular psychiatry · 2025Article
- Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy.Pharmacological reviews · 2025Review
- Antidepressant Use Before, During, and After Pregnancy.JAMA network open · 2025Article
- Management of postnatal depression: A systematic review of clinical practice guidelines.Global mental health (Cambridge, England) · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSeveral countries have developed Clinical Practice Guidelines regarding treatment of perinatal depressive symptoms and perinatal use of antidepressant. We aimed to compare guidelines to guide clinicians in best clinical practice.
methodsAn extensive search in guideline databases, MEDLINE and PsycINFO was performed. When no guidelines were (publicly) available online, we contacted psychiatric-, obstetric-, perinatal- and mood disorder societies of all first world countries and the five largest second world countries. Only Clinical Practice Guidelines adhering to quality criteria of the Appraisal of Guidelines for Research and Evaluation instrument and including a systematic review of evidence were included. Data extraction focussed on recommendations regarding continuation or withdrawal of antidepressants and preferred treatment in newly depressed patients.
resultsOur initial search resulted in 1094 articles. After first screening, 40 full-text articles were screened. Of these, 24 were excluded for not being an official Clinical Practice Guidelines. In total, 16 Clinical Practice Guidelines were included originating from 12 countries. Eight guidelines were perinatal specific and eight were general guidelines.
conclusionDuring pregnancy, four guidelines advise to continue antidepressants, while there is a lack of evidence supporting this recommendation. Five guidelines do not specifically advise or discourage continuation. For new episodes, guidelines agree on psychotherapy (especially cognitive behavioural therapy) as initial treatment for mild to moderate depression and antidepressants for severe depression, with a preference for sertraline. Paroxetine is not preferred treatment for new episodes but switching antidepressants for ongoing treatment is discouraged (three guidelines). If mothers use antidepressants, observation of the neonate is generally recommended and breastfeeding encouraged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.