ArticleAmerican journal of epidemiology2018
The Role of Mobile Genetic Elements in the Spread of Antimicrobial-Resistant Escherichia coli From Chickens to Humans in Small-Scale Production Poultry Operations in Rural Ecuador.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Transmission routes of antibiotic resistant bacteria: a systematic review.BMC infectious diseases · 2022Pooled it
- Genomic Surveillance of ESBL-ProducingPathogens (Basel, Switzerland) · 2026Article
- Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance.MedComm · 2026Review
- Cell-Free but potent: Antimicrobial potential of Lactobacillus supernatants against multidrug-resistant pathogens.PloS one · 2026Article
- Transfer potential of F-like plasmids inISME communications · 2026Article
- Antimicrobial resistance within the one health lens: global drivers, mechanisms and public health policy gaps in low resource settings.Frontiers in cellular and infection microbiology · 2026Review
- Environmental exposures associated with the gut microbiome and resistome of pregnant women and children in Northwest Ecuador.Nature communications · 2025Article
- Historical Overview of the Evolution of Multidrug-Resistant Gram-Negative Infections in Tunisia from 1999 to 2019.Antibiotics (Basel, Switzerland) · 2025Article
- Environmental Exposures and the Human Gut Resistome in Northwest Ecuador.medRxiv : the preprint server for health sciences · 2025Article
- Distributive justice and value trade-offs in antibiotic use in aged care settings.Monash bioethics review · 2024Article
- A nationwide survey of antimicrobial resistance ofJAC-antimicrobial resistance · 2024Article
- Detecting Class 1 Integrons and Their Variable Regions inAntibiotics (Basel, Switzerland) · 2024Article
- Mobilome-driven partitions of the resistome inmSystems · 2023Article
- Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Using a combination of short- and long-read sequencing to investigate the diversity in plasmid- and chromosomally encoded extended-spectrum beta-lactamases (ESBLs) in clinicalMicrobial genomics · 2023Article
- Antibiotic resistance genes of public health importance in livestock and humans in an informal urban community in Nepal.Scientific reports · 2022Article
- A bottom-up view of antimicrobial resistance transmission in developing countries.Nature microbiology · 2022Review
- Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Risk factors for third-generation cephalosporin-resistant and extended-spectrum β-lactamase-producing Escherichia coli carriage in domestic animals of semirural parishes east of Quito, Ecuador.PLOS global public health · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Small-scale production poultry operations are increasingly common worldwide. To investigate how these operations influence antimicrobial resistance and mobile genetic elements (MGEs), Escherichia coli isolates were sampled from small-scale production birds (raised in confined spaces with antibiotics in feed), household birds (no movement constraints; fed on scraps), and humans associated with these birds in rural Ecuador (2010-2012). Isolates were screened for genes associated with MGEs as well as phenotypic resistance to 12 antibiotics. Isolates from small-scale production birds had significantly elevated odds of resistance to 7 antibiotics and presence of MGE genes compared with household birds (adjusted odds ratio (OR) range = 2.2-87.9). Isolates from humans associated with small-scale production birds had elevated odds of carrying an integron (adjusted OR = 2.0; 95% confidence interval (CI): 1.06, 3.83) compared with humans associated with household birds, as well as resistance to sulfisoxazole (adjusted OR = 1.9; 95% CI: 1.01, 3.60) and trimethoprim/sulfamethoxazole (adjusted OR = 2.1; 95% CI: 1.13, 3.95). Stratifying by the presence of MGEs revealed antibiotic groups that are explained by biological links to MGEs; in particular, resistance to sulfisoxazole, trimethoprim/sulfamethoxazole, or tetracycline was highest among birds and humans when MGE exposures were present. Small-scale production poultry operations might select for isolates carrying MGEs, contributing to elevated levels of resistance in this setting.
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Registered trials
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