ArticleMedicine2018
Familial Mediterranean fever mimicking Crohn disease: A case report.
Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of Mediterranean Fever Gene Mutations on Clinical Characteristics in Patients With Inflammatory Bowel Disease.Gastro hep advances · 2026Article
- Colitis in a patient with familial Mediterranean fever: Is it Crohn's disease or ulcerative colitis?DEN open · 2025Article
- Familial Mediterranean Fever Mimicking Metastatic Crohn's Disease.ACG case reports journal · 2024Article
- Accuracy of generative artificial intelligence models in differential diagnoses of familial Mediterranean fever and deficiency of Interleukin-1 receptor antagonist.Journal of translational autoimmunity · 2023Article
- Familial Mediterranean Fever Mimicking Whipple's Disease: A Case Report and Review of the Literature.Mediterranean journal of rheumatology · 2022Article
- Mediterranean fever gene-associated enterocolitis in an elderly Japanese woman.Clinical journal of gastroenterology · 2021Article
- Contradictory Effects of NLRP3 Inflammasome Regulatory Mechanisms in Colitis.International journal of molecular sciences · 2020Review
- FMF is not always "fever": from clinical presentation to "treat to target".Italian journal of pediatrics · 2020Review
- Frequency of functional gastrointestinal disorders in children with familial Mediterranean fever.Clinical rheumatology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleFamilial Mediterranean fever (FMF) is the most common form of autoinflammatory disease. We report a rare case of FMF with gastrointestinal lesions mimicking Crohn disease. PATIENT CONCERNS: A 21-year-old Japanese man was referred to our institution, complaining of refractory diarrhea and weight loss of 14 kg during the past two years. He had presented with recurrent fever, abdominal pain, anal fistula and stomatitis. His father and one of his brothers had ulcerative colitis. Colonoscopy revealed longitudinal ulcers in the terminal ileum and aphthous erosions in the colorectum. Esophagogastroduodenoscopy revealed multiple linear erosions in the gastric corpus and circular erosions in the duodenal second portion. Biopsy from these lesions failed to detect epithelioid cell granulomas. DIAGNOSES: Analysis of the genomic DNA revealed compound heterozygous mutations of E148Q/L110P in exon 2 of MEFV gene, suggesting a diagnosis of FMF.
interventionsThe patient was subsequently given 0.5 mg of colchicine per day. OUTCOMES: Follow-up colonoscopy 6 months later demonstrated that both the longitudinal ulcers in the terminal ileum and aphthous lesions in the colorectum had completely disappeared. LESSONS: Our case suggests that patients with FMF possibly manifest gastrointestinal lesions mimicking Crohn disease.
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