Observational studyMedicine2018
Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children.
Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Vitamin D status was associated with sepsis in critically ill children: A PRISMA compliant systematic review and meta-analysis.Medicine · 2021Pooled it
- The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies.Medicine · 2019Pooled it
- Pooled it
- Trial
- Clinical Study of Vitamin D Levels in Hospitalized Children with Acute Respiratory Infections.Pediatric reports · 2024Article
- Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review.BMC public health · 2024Review
- Review
- Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19.Pediatric research · 2023Article
- Review
- 25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFβ-mediated nuclear translocation mechanism of YAP/TAZ.Bioengineered · 2021Article
- Serum 25-hydroxyvitamin D concentration and infectious respiratory disease complex in shelter dogs.Journal of veterinary internal medicine · 2021Article
- Is vitamin D deficiency a risk factor for COVID-19 in children?Pediatric pulmonology · 2020Article
- The Role of Micronutrients in Support of the Immune Response against Viral Infections.Nutrients · 2020Review
- Effects of calcitriol on oxidative burst, phagocytic function, and leukocyte cytokine production in shelter dogs.Canine medicine and genetics · 2020Article
- Vitamin D Deficiency is Associated with Increased Use of Antimicrobials among Preschool Girls in Ethiopia.Nutrients · 2019Article
- Vitamin D and Acute Respiratory Infections in Children.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and community-acquired pneumonia (CAP) among Chinese children.This observational study examined children aged 3 days to 14 years (n = 1582) from the Capital Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 25.32 ± 14.07 ng/mL, with the CAP group showing a lower value than the control group (P < .001). There were also significant differences between the pneumonia group and pneumonia-induced sepsis group (P < .001). In the pneumonia-induced sepsis group, significant differences in serum 25(OH)D levels were observed in children who received mechanical ventilation or presenting with multiple organ dysfunction (P < .01).All serum 25(OH)D levels in the pneumonia group and pneumonia-induced sepsis group were below normal levels, particularly in the sepsis group. A lower serum 25(OH)D level was associated with more serious symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher risk of receiving mechanical ventilation and presenting with multiple organ dysfunction. These findings suggest that vitamin D supplements are beneficial for the treatment and prevention of CAP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.