Evidence map›Paper›PMID 29505303›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.

Kellie A Woll, Xiaojuan Zhou, Natarajan V Bhanu, Benjamin A Garcia, Manuel Covarrubias, Keith W Miller, Roderic G Eckenhoff

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Precisely Providing Analgesia through Selectively Targeting the GABAThe Journal of pharmacology and experimental therapeutics · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. αACS chemical neuroscience · 2022
    Article
  18. Review
  19. Review
  20. GABAFrontiers in aging neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kellie A WollDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xiaojuan ZhouDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Natarajan V BhanuDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Benjamin A GarciaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Manuel CovarrubiasDepartment of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Keith W MillerDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Roderic G EckenhoffDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USMassachusetts General Hospital · USThomas Jefferson University · US

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ECKENHOFF, RODERIC G · 1997 to 2017
$22.4M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
Understanding the Role of Combinatorial Histone PTM PatternsR01GM110174 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GARCIA, BENJAMIN A · 2014 to 2017
$1.3M
OptoanesthesiaR01GM107117 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2014 to 2017
$1.3M
NIAID NIH HHS R01 AI118891NIGMS NIH HHS P01 GM055876NIGMS NIH HHS P01 GM058448NIGMS NIH HHS R01 GM107117NIGMS NIH HHS R01 GM110174
6 · The paper itself

Abstract

Most general anesthetics enhance GABA type A (GABA

Indexed as

AnestheticsAnimalsBinding SitesCell LineHumansIsofluraneMembrane ProteinsOocytesReceptors, GABA-ASevofluraneXenopus laevisAnestheticsIsofluraneMembrane ProteinsReceptors, GABA-ASevofluranecrosslinkingisofluranephotoaffinity labelingsevoflurane

Identifiers

PMID29505303
PMCPMC6044061
OpenAlexW2790867446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.