Trial reportJPEN. Journal of parenteral and enteral nutrition2018
High-Dose Vitamin D
Trial report in JPEN. Journal of parenteral and enteral nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Vitamin D supplementation in critically ill patients: a meta-analysis.Frontiers in nutrition · 2025Pooled it
- Has a High Dose of Vitamin D3 Impacted Health Conditions in Older Adults?-A Systematic Review and Meta-Analysis Focusing on Dose 100,000 IU.Nutrients · 2024Pooled it
- The effect of vitamin D supplementation on hemoglobin concentration: a systematic review and meta-analysis.Nutrition journal · 2020Pooled it
- The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease.BMC nephrology · 2023Trial
- Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths.Critical care (London, England) · 2019Trial
- Randomized supplementation of 4000 IU vitamin DNutrition journal · 2017Trial
- Treatment of Hypovitaminosis D Is Associated with Improvement in Anemia of Inflammation in Patients with Decompensated Cirrhosis.Medical sciences (Basel, Switzerland) · 2026Article
- Vitamin D Supplementation in Critically Ill-Narrative Review.Nutrients · 2024Review
- Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy.European journal of medicinal chemistry · 2022Review
- Article
- Article
- Physiology and Inflammation Driven Pathophysiology of Iron Homeostasis-Mechanistic Insights into Anemia of Inflammation and Its Treatment.Nutrients · 2021Review
- Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein.Scientific reports · 2021Article
- Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review.Nutrients · 2021Review
- Reply to: vitamin D supplementation and hemoglobin: dosing matters in prevention/treatment of anemia.Nutrition journal · 2021Article
- Cancer Related Anemia: An Integrated Multitarget Approach and Lifestyle Interventions.Nutrients · 2021Review
- Can Optimum Solar Radiation Exposure or Supplemented Vitamin D Intake Reduce the Severity of COVID-19 Symptoms?International journal of environmental research and public health · 2021Review
- Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.The journal of trauma and acute care surgery · 2020Observational
- Challenges of Maintaining Optimal Nutrition Status in COVID-19 Patients in Intensive Care Settings.JPEN. Journal of parenteral and enteral nutrition · 2020Review
- Key Aspects in Nutritional Management of COVID-19 Patients.Journal of clinical medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAnemia and vitamin D deficiency are highly prevalent in critical illness, and vitamin D status has been associated with hemoglobin concentrations in epidemiologic studies. We examined the effect of high-dose vitamin D therapy on hemoglobin and hepcidin concentrations in critically ill adults. MATERIALS AND
methodsMechanically ventilated critically ill adults (N = 30) enrolled in a pilot double-blind, randomized, placebo-controlled trial of high-dose vitamin D
resultsAt enrollment, >75% of participants in all groups had plasma 25-hydroxyvitamin D (25(OH)D) concentrations <30 ng/mL, and >85% of participants across groups were anemic. In the 500,000-IU D
conclusionIn these critically ill adults, treatment with 500,000 IU D
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.