Evidence map›Paper›PMID 29504949›Full record

ArticleThe Journal of clinical investigation2018

Osteoclast-secreted SLIT3 coordinates bone resorption and formation.

Beom-Jun Kim, Young-Sun Lee, Sun-Young Lee, Wook-Young Baek, Young Jin Choi, Sung Ah Moon, Seung Hun Lee, Jung-Eun Kim, Eun-Ju Chang, Eun-Young Kim and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.

  1. Pooled it
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  11. Osteoclast-Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  19. The Interplay of Angiogenesis and Osteogenesis in Non-Stabilized Incomplete Tibial Fractures: A Temporal Study in Rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Beom-Jun KimDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Young-Sun LeeAsan Institute for Life Sciences, Seoul, South Korea.
Sun-Young LeeAsan Institute for Life Sciences, Seoul, South Korea.
Wook-Young BaekAsan Institute for Life Sciences, Seoul, South Korea.
Young Jin ChoiAsan Institute for Life Sciences, Seoul, South Korea.
Sung Ah MoonAsan Institute for Life Sciences, Seoul, South Korea.
Seung Hun LeeDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jung-Eun KimDepartment of Molecular Medicine, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, South Korea.
Eun-Ju ChangDepartment of Biomedical Sciences, and.
Eun-Young KimDepartment of Biomedical Sciences, and.
Jin YoonDepartment of Pharmacology, University of Ulsan College of Medicine, Seoul, South Korea.
Seung-Whan KimDepartment of Pharmacology, University of Ulsan College of Medicine, Seoul, South Korea.
Sung Ho RyuDepartment of Life Science, Pohang University of Science and Technology, Pohang, Kyungbook, South Korea.
Sun-Kyeong LeeUConn Center on Aging and.
Joseph A LorenzoDepartments of Medicine and Orthopaedics, University of Connecticut Health Center, Farmington, Connecticut, USA.
Seong Hee AhnDepartment of Internal Medicine, Inha University School of Medicine, Incheon, South Korea.
Hyeonmok KimDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Ki-Up LeeDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Ghi Su KimDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jung-Min KohDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Ulsan College · KRAsan Medical Center · KRInha University · KRKyungpook National University · KRPohang University of Science and Technology · KRUConn Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coupling is the process that links bone resorption to bone formation in a temporally and spatially coordinated manner within the remodeling cycle. Several lines of evidence point to the critical roles of osteoclast-derived coupling factors in the regulation of osteoblast performance. Here, we used a fractionated secretomic approach and identified the axon-guidance molecule SLIT3 as a clastokine that stimulated osteoblast migration and proliferation by activating β-catenin. SLIT3 also inhibited bone resorption by suppressing osteoclast differentiation in an autocrine manner. Mice deficient in Slit3 or its receptor, Robo1, exhibited osteopenic phenotypes due to a decrease in bone formation and increase in bone resorption. Mice lacking Slit3 specifically in osteoclasts had low bone mass, whereas mice with either neuron-specific Slit3 deletion or osteoblast-specific Slit3 deletion had normal bone mass, thereby indicating the importance of SLIT3 as a local determinant of bone metabolism. In postmenopausal women, higher circulating SLIT3 levels were associated with increased bone mass. Notably, injection of a truncated recombinant SLIT3 markedly rescued bone loss after an ovariectomy. Thus, these results indicate that SLIT3 plays an osteoprotective role by synchronously stimulating bone formation and inhibiting bone resorption, making it a potential therapeutic target for metabolic bone diseases.

Indexed as

Autocrine CommunicationOsteogenesisAnimalsBone Diseases, MetabolicBone ResorptionCell DifferentiationFemaleHumansMaleMembrane ProteinsMiceMice, KnockoutNerve Tissue ProteinsOsteoblastsOsteoclastsReceptors, ImmunologicMembrane ProteinsNerve Tissue ProteinsReceptors, ImmunologicRoundabout ProteinsSLIT3 protein, humanSlit3 protein, mouseBone BiologyCoupling factors

Identifiers

PMID29504949
PMCPMC5873876
OpenAlexW2792461570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.