Trial reportJournal of consulting and clinical psychology2018
Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.
Trial report in Journal of consulting and clinical psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04956341 (Auricular Acupuncture for Sleep Disturbances), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Auricular Acupuncture for Sleep Disturbances: A Randomized Control Trial
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of psychological treatments to improve sleep quality in university students.PloS one · 2025Pooled it
- Efficacy and safety of Kami Guibi-tang in older adults with insomnia and memory complaints: a randomized, double-blind, placebo-controlled pilot trial.BMC complementary medicine and therapies · 2026Trial
- Acupuncture for comorbid depression and insomnia in perimenopause: A feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial.Frontiers in public health · 2023Trial
- Effect of Sleep Disturbance Symptoms on Treatment Outcome in Blended Cognitive Behavioral Therapy for Depression (E-COMPARED Study): Secondary Analysis.Journal of medical Internet research · 2022Trial
- Is sleep disturbance linked to short- and long-term outcomes following treatments for recurrent depression?Journal of affective disorders · 2020Trial
- The Relationship of Early Sleep Improvement With Response to Pharmacotherapy in Unipolar Psychotic Depression.Journal of clinical psychopharmacologyTrial
- Exposome factors predict the association between sleep health and depression.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive behavioral therapy for menopausal insomnia in perimenopausal and postmenopausal women with insomnia and nocturnal hot flashes: a randomized-controlled pilot trial.Menopause (New York, N.Y.) · 2026Article
- Integrating multi-polygenic scores for enhanced prediction of antidepressant treatment outcomes in an East Asian population.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- The effect of psychotherapy on the multivariate association between insomnia and depressive symptoms in late-life depression.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Acceptance and commitment therapy for psychiatric inpatients diagnosed with depression and insomnia: a multiple-baseline single-case study.Frontiers in psychiatry · 2025Article
- Sleep effort and its measurement: A scoping review.Journal of sleep research · 2024Article
- Article
- Preferences of University Students for a Psychological Intervention Designed to Improve Sleep: Focus Group Study.JMIR human factors · 2023Article
- Article
- Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Pathways to Anxiety and Depression in Autistic Adolescents and Adults.Depression and anxiety · 2023Article
- Baseline symptoms of depression and anxiety negatively impact the effectiveness of CBTi in treating acute insomnia among young adults.General psychiatry · 2023Article
- Mindfulness-based cognitive therapy improves insomnia symptoms in individuals with recurrent depression: secondary analyses from a randomized controlled trial.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveInsomnia and major depressive disorders (MDD) often co-occur, and such comorbidity has been associated with poorer outcomes for both conditions. However, individual differences in depressive symptom trajectories during and after treatment are poorly understood in comorbid insomnia and depression. This study explored the heterogeneity in long-term depression change trajectories, and examined their correlates, particularly insomnia-related characteristics.
methodParticipants were 148 adults (age M ± SD = 46.6 ± 12.6, 73.0% female) with insomnia and MDD who received antidepressant pharmacotherapy, and were randomized to 7-session Cognitive Behavioral Therapy for Insomnia or control conditions over 16 weeks with 2-year follow-ups. Depression and insomnia severity were assessed at baseline, biweekly during treatment, and every 4 months thereafter. Sleep effort and beliefs about sleep were also assessed.
resultsGrowth mixture modeling revealed three trajectories: (a) Partial-Responders (68.9%) had moderate symptom reduction during early treatment (p value < .001) and maintained mild depression during follow-ups. (b) Initial-Responders (17.6%) had marked symptom reduction during treatment (p values < .001) and low depression severity at posttreatment, but increased severity over follow-up (p value < .001). (c) Optimal-Responders (13.5%) achieved most gains during early treatment (p value < .001), continued to improve (p value < .01) and maintained minimal depression during follow-ups. The classes did not differ significantly on baseline measures or treatment received, but differed on insomnia-related measures after treatment began (p values < .05): Optimal-Responders consistently endorsed the lowest insomnia severity, sleep effort, and unhelpful beliefs about sleep.
conclusionsThree depression symptom trajectories were observed among patients with comorbid insomnia and MDD. These trajectories were associated with insomnia-related constructs after commencing treatment. Early changes in insomnia characteristics may predict long-term depression outcomes. (PsycINFO Database Record
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.