Evidence map›Paper›PMID 29504794›Full record

Trial reportJournal of consulting and clinical psychology2018

A randomized controlled trial of emotion regulation therapy for generalized anxiety disorder with and without co-occurring depression.

Douglas S Mennin, David M Fresco, Mia Skytte O'Toole, Richard G Heimberg

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of consulting and clinical psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04060940 nacompletednot on this map

Emotion Regulation Therapy for Young Adults With Clinical Worry and Rumination

TypeinterventionalSponsorDouglas MenninRan2015 to 2022Enrolled72ConditionsAnxiety Disorders and Symptoms, Depression, Anxiety, Generalized Anxiety Disorder, Emotional DysfunctionArmsEmotion Regulation Therapy: 8-session version, Emotion Regulation Therapy: 16-session version
NCT04615416 nacompletednot on this mapstarted 2020, after this paper: background citation

Open Trial of Emotion Regulation Training Via Telehealth for Distressed Adults During the COVID-19 Pandemic

TypeinterventionalSponsorTeachers College, Columbia UniversityRan2020 to 2024Enrolled134ConditionsDistress, Emotional, Emotional Dysfunction, Anxiety, DepressionArmsEmotion Regulation Training via Telehealth
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Douglas S MenninDepartment of Counseling and Clinical Psychology, Teachers College, Columbia University.
David M FrescoDepartment of Psychological Sciences, Kent State University.ORCID 0000-0001-6736-3912
Mia Skytte O'TooleDepartment of Psychological and Behavioral Sciences, Aarhus University.ORCID 0000-0002-9155-8426
Richard G HeimbergDepartment of Psychology, Temple University.
Kent State University · USAarhus University · DKTemple College · US

Funding

Mindfulness-Based Stress Reduction for High Blood Pressure: A Two-Site RCTR01HL119977 · NHLBI · KENT STATE UNIVERSITY · PI FRESCO, DAVID M · 2014 to 2018
$3.8M
SMART Center II Brain Behavior Connections in Self Management ScienceP30NR015326 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI DECKER, MICHAEL JOHN · 2014 to 2018
$2.8M
Emotion Regulation Therapy for Generalized AnxietyR34MH070682 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI HEIMBERG, RICHARD G · 2006 to 2008
$628k
NHLBI NIH HHS R01 HL119977NIMH NIH HHS R34 MH070682NINR NIH HHS P30 NR015326
6 · The paper itself

Abstract

objectiveGeneralized anxiety disorder (GAD) and major depression (MDD), especially when they co-occur, are associated with suboptimal treatment response. One common feature of these disorders is negative self-referential processing (NSRP; i.e., worry, rumination), which worsens treatment outcome. Emotion Regulation Therapy (ERT) integrates principles from affect science with traditional and contemporary cognitive-behavioral treatments to identify and modify the functional nature of NSRP by targeting motivational and regulatory mechanisms, as well as behavioral consequences.

methodBuilding on encouraging open trial findings, 53 patients with a primary diagnosis of GAD (43% with comorbid MDD) were randomly assigned to immediate treatment with ERT (n = 28) or a modified attention control condition (MAC, n = 25).

resultsERT patients, as compared with MAC patients, evidenced statistically and clinically meaningful improvement on clinical indicators of GAD and MDD, worry, rumination, comorbid disorder severity, functional impairment, quality of life, as well as hypothesized mechanisms reflecting mindful attentional, metacognitive, and overall emotion regulation, which all demonstrated mediation of primary outcomes. This superiority of ERT exceeded medium effect sizes with most outcomes surpassing conventions for a large effect. Treatment effects were maintained for nine months following the end of acute treatment. Overall, ERT resulted in high rates of high endstate functioning for both GAD and MDD that were maintained into the follow-up period.

conclusionsFindings provide encouraging support for the efficacy and hypothesized mechanisms underlying ERT and point to fruitful directions for improving our understanding and treatment of complex clinical conditions such as GAD with co-occurring MDD. (PsycINFO Database Record

Indexed as

Cognitive Behavioral TherapyMindfulnessAnxiety DisordersDepressionEmotionsHumansMetacognitionMotivationQuality of LifeTreatment Outcome

Identifiers

PMID29504794
PMCPMC5841545
OpenAlexW2792164547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.