Evidence map›Paper›PMID 29504753›Full record

ArticleACS sensors2018

Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis.

Denis Svechkarev, Marat R Sadykov, Kenneth W Bayles, Aaron M Mohs

Abstract read
In one paragraph

Article in ACS sensors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  7. Review
  8. Machine learning assisted identification of antibiotic-resistantMicrochemical journal : devoted to the application of microtechniques in all branches of science · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Nanotechnology for Targeted Detection and Removal of Bacteria: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  16. Review
  17. [Application of carbon dots in analysis and detection of antibiotics].Se pu = Chinese journal of chromatography · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Denis SvechkarevDepartment of Pharmaceutical Sciences , University of Nebraska Medical Center , Omaha , Nebraska 68198-6858 , United States.ORCID 0000-0002-4002-6155
Marat R SadykovDepartment of Pathology and Microbiology , University of Nebraska Medical Center , Omaha , Nebraska 68198-5900 , United States.
Kenneth W BaylesDepartment of Pathology and Microbiology , University of Nebraska Medical Center , Omaha , Nebraska 68198-5900 , United States.ORCID 0000-0001-9521-3540
Aaron M MohsDepartment of Pharmaceutical Sciences , University of Nebraska Medical Center , Omaha , Nebraska 68198-6858 , United States.ORCID 0000-0002-9353-5404
University of Nebraska Medical Center · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Apar Kishor Ganti · 1985 to 2026
$55.0M
The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2009 to 2023
$32.1M
The molecular control of bacterial programmed cell deathR01AI125589 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2016 to 2020
$1.9M
Upgrade of mass spectrometer facilityS10RR017846 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMAS, MICHAEL J · 2003 to 2003
$497k
Replacement of GC Mass SpectrometerS10RR027940 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMAS, MICHAEL J · 2010 to 2010
$209k
NCI NIH HHS P30 CA036727NCRR NIH HHS S10 RR017846NCRR NIH HHS S10 RR027940NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125589
6 · The paper itself

Abstract

Rapid and reliable identification of pathogenic microorganisms is of great importance for human and animal health. Most conventional approaches are time-consuming and require expensive reagents, sophisticated equipment, trained personnel, and special storage and handling conditions. Sensor arrays based on small molecules offer a chemically stable and cost-effective alternative. Here we present a ratiometric fluorescent sensor array based on the derivatives of 2-(4'- N, N-dimethylamino)-3-hydroxyflavone and investigate its ability to provide a dual-channel ratiometric response. We demonstrate that, by using discriminant analysis of the sensor array responses, it is possible to effectively distinguish between eight bacterial species and recognize their Gram status. Thus, multiple parameters can be derived from the same data set. Moreover, the predictive potential of this sensor array is discussed, and its ability to analyze unknown samples beyond the list of species used for the training matrix is demonstrated. The proposed sensor array and analysis strategies open new avenues for the development of advanced ratiometric sensors for multiparametric analysis.

Indexed as

FluorescenceAnimalsFlavonoidsFluorescent DyesGram-Negative BacteriaGram-Positive BacteriaHumansSpectrometry, Fluorescence3-hydroxyflavoneFlavonoidsFluorescent Dyes3-hydroxyflavonechemical nosediscriminant analysisESIPTGram statusmultiparametric sensingpattern analysispredictive analysis

Identifiers

PMID29504753
PMCPMC5938749
OpenAlexW2791665019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.