ArticleJournal of musculoskeletal & neuronal interactions2018
Expression of BDNF in dorsal root ganglion of rats with bone cancer pain and its effect on pain behavior.
Article in Journal of musculoskeletal & neuronal interactions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Tumor-nerve crosstalk: peripheral mechanisms mediating bone tumor progression and cancer-induced bone pain.Frontiers in oncology · 2026Review
- Tetrahydropalmatine has analgesic role in mouse model of bone cancer pain by inactivating the TNF-α/uPA/PAR2/TRPV1 pathway in dorsal root ganglia.Cancer cell international · 2025Article
- Calcium Signalling in Breast Cancer Associated Bone Pain.International journal of molecular sciences · 2022Review
- Neurophysiological mechanisms of cancer-induced bone pain.Journal of advanced research · 2022Review
- Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis.Physiological reports · 2021Article
- Distinct Gene Expression Patterns of Ion Channels and Cytokines in Rat Primary Sensory Neurons During Development of Bone Cancer and Cancer Pain.Frontiers in molecular neuroscience · 2021Article
- Assessing Pain Behavioral Responses and Neurotrophic Factors in the Dorsal Root Ganglion, Serum and Peritoneal Fluid in Rat Models of Endometriosis.Journal of family & reproductive health · 2020Article
- Novel Analgesics with Peripheral Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- [Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain.Molecular painArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo detect the expression of brain-derived neurotrophic factor (BDNF) in dorsal root ganglion (DRG) of rats with bone cancer pain, and to explore the effects of BDNF and anti-BDNF on pain behavior.
methods40 SD rats were randomly divided into Sham group and Cancer group (n=20). Rats in Sham were injected with PBS into the tibia, while rats in Cancer group were injected with Walker 256 cells to construct rat tibial bone cancer pain model. Rats in Cancer group were further divided into physiological saline (NS) group and anti-BDNF group (n=10) to observe the effects of anti-BDNF on pain behavior in rats with bone cancer pain.
resultsExpression level of BDNF and its receptor in DRG of Cancer group was significantly higher than that of Sham group at 3 weeks after inoculation (p⟨0.05). The expression level of BDNF mRNA in the Cancer group was significantly higher than that in the Sham group at 5d, 10d and 20d (p⟨0.05). Hindpaw withdrawal latency was significantly shorter in Cancer group than in Sham group (p⟨0.05). Hindpaw withdrawal mechanical threshold was significantly lower in Cancer group than in Sham group (p⟨0.05). Hindpaw withdrawal latency was significantly longer and hindpaw withdrawal mechanical threshold was significantly higher in anti-BDNF group than in NS group after the use of anti-BDNF (p⟨0.05).
conclusionBDNF can aggravate bone pain in rats, and anti-BDNF has obvious antinociceptive function in bone cancer pain.
Indexed as
Identifiers
29504577PMC5881127W2981078049What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.