ArticleJournal of musculoskeletal & neuronal interactions2018
Calf muscle density is independently associated with physical function in overweight and obese older adults.
Article in Journal of musculoskeletal & neuronal interactions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals.Journal of the International Society of Sports Nutrition · 2020Trial
- Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide.Reviews in endocrine & metabolic disorders · 2025Review
- Review
- Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals.GeroScience · 2024Article
- Investigating the Effects of Diet-Induced Prediabetes on Skeletal Muscle Strength in Male Sprague Dawley Rats.International journal of molecular sciences · 2024Article
- The use of non-invasive imaging modalities for the assessment of skeletal muscle quantity and quality in people with HIV: A narrative review.HIV medicine · 2023Review
- A comprehensive review on the risks assessment and treatment options for Sarcopenia in people with diabetes.Journal of diabetes and metabolic disorders · 2023Review
- Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies.Diabetes & metabolism journal · 2023Review
- Article
- The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Differences in Muscle Quantity and Quality by HIV Serostatus and Sex.The Journal of frailty & aging · 2022Article
- Effects of a 3-Week Inpatient Multidisciplinary Body Weight Reduction Program on Body Composition and Physical Capabilities in Adolescents and Adults With Obesity.Frontiers in nutrition · 2022Article
- Obesity-associated poor muscle quality: prevalence and association with age, sex, and body mass index.BMC musculoskeletal disorders · 2020Observational
- Associations of Serum 25-Hydroxyvitamin D with Physical Performance and Bone Health in Overweight and Obese Older Adults.International journal of environmental research and public health · 2019Article
- Metabolic Syndrome and Its Associations with Components of Sarcopenia in Overweight and Obese Older Adults.Journal of clinical medicine · 2019Article
- Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether associations of calf muscle density with physical function are independent of other determinants of functional decline in overweight and obese older adults.
methodsThis was a secondary analysis of a cross-sectional study of 85 community-dwelling overweight and obese adults (mean±SD age 62.8±7.9 years; BMI 32.3±6.1 kg/m2; 58% women). Peripheral quantitative computed tomography assessed mid-calf muscle density (66% tibial length) and dual-energy X-ray absorptiometry determined visceral fat area. Fasting glucose, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and C-reactive protein (CRP) were analysed. Physical function assessments included hand grip and knee extension strength, balance path length (computerised posturography), stair climb test, Short Physical Performance Battery (SPPB) and self-reported falls efficacy (Modified Falls Efficacy Scale; M-FES).
resultsVisceral fat area, not muscle density, was independently associated with CRP and fasting glucose (B=0.025; 95% CI 0.009-0.042 and B=0.009; 0.001-0.017, respectively). Nevertheless, higher muscle density was independently associated with lower path length and stair climb time, and higher SPPB and M-FES scores (all P⟨0.05). Visceral fat area, fasting glucose and CRP did not mediate these associations.
conclusionsHigher calf muscle density predicts better physical function in overweight and obese older adults independent of insulin resistance, visceral adiposity or inflammation.
Indexed as
Identifiers
29504574PMC5881124W2801682122What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.