Evidence map›Paper›PMID 29504242›Full record

ArticleJournal of thrombosis and haemostasis : JTH2018

Vasomotor symptoms and the risk of incident venous thrombosis in postmenopausal women.

L B Harrington, M Blondon, M Cushman, A M Kaunitz, M A Allison, L Wang, S Sullivan, N F Woods, A Z LaCroix, S R Heckbert and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

L B HarringtonDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
M BlondonDivision of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
M CushmanDepartment of Medicine, University of Vermont, Burlington, VT, USA.ORCID 0000-0002-7871-6143
A M KaunitzDepartment of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.
M A AllisonDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
L WangDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
S SullivanDepartment of Endocrinology, Medstar Georgetown University Hospital and Medstar Washington Hospital Center, Washington, DC, USA.
N F WoodsSchool of Nursing, University of Washington, Seattle, WA, USA.
A Z LaCroixDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
S R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
B McKnightDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
J RossouwNational Heart Lung and Blood Institute, Bethesda, MD, USA.
N L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
University of Washington · USUniversity of California San Diego · USBrigham and Women's Hospital · USGeorgetown University · USGroup Health Cooperative · USHarvard University · USNational Heart Lung and Blood Institute · USUniversity of Florida · USUniversity of Vermont · US

Funding

CVD Epidemiology Training Program in Behavior, the Environment and Global HealthT32HL098048 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Goodarz Danaei, ERIC B RIMM · 2009 to 2026
$6.9M
CVD Epidemiology Training ProgramT32HL007902 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1998 to 2012
$3.6M
The Association of Vasomotor Symptoms with Thrombosis in Postmenopausal WomenR21HL121414 · NHLBI · UNIVERSITY OF WASHINGTON · PI SMITH, NICHOLAS L · 2014 to 2015
$184k
NHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS R21 HL121414NHLBI NIH HHS T32 HL007902NHLBI NIH HHS T32 HL098048NIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Essentials Vasomotor symptoms have been proposed as markers of changing cardiovascular risk. In this cohort study, we evaluated these symptoms as markers of venous thrombosis (VT) risk. We found no evidence that vasomotor symptom presence or severity were associated with VT risk. Among these postmenopausal women, vasomotor symptoms are not a useful marker of VT risk. SUMMARY: Background Vasomotor symptoms may be markers of changes in cardiovascular risk, but it is unknown whether these symptoms are associated with the risk of venous thrombosis (VT). Objective To evaluate the association of vasomotor symptom presence and severity with incident VT risk among postmenopausal women, independent of potential explanatory variables. Methods This cohort study included participants of the Women's Health Initiative (WHI) Hormone Therapy Trials (n = 24 508) and Observational Study (n = 87 783), analyzed separately. At baseline, women reported whether hot flashes or night sweats were present and, if so, their severity. Using Cox proportional hazards models, we estimated the VT risk associated with vasomotor symptom presence and severity, adjusted for potential explanatory variables: age, body mass index, smoking status, race/ethnicity, and time-varying current hormone therapy use. Results At baseline, WHI Hormone Therapy Trial participants were aged 64 years and WHI Observational Study participants were aged 63 years, on average. In the WHI Hormone Therapy Trials over a median of 8.2 years of follow-up, 522 women experienced a VT event. In the WHI Observational Study, over 7.9 years of follow-up, 1103 women experienced a VT event. In adjusted analyses, we found no evidence of an association between vasomotor symptom presence (hazard ratio [HR]

Indexed as

PostmenopauseSweatingAgedFemaleHot FlashesHumansIncidenceMiddle AgedObservational Studies as TopicPrognosisRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsUnited Statesdeep vein thrombosisepidemiologyhot flashespostmenopausepulmonary embolismvenous thrombosis

Identifiers

PMID29504242
PMCPMC5932241
OpenAlexW2790164571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.