ArticleHuman brain mapping2018
Reduced corticostriatal functional connectivity in temporomandibular disorders.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.Neural plasticity · 2026Pooled it
- The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies.The journal of headache and pain · 2020Pooled it
- Review
- Investigating changes of functional brain networks in painful temporomandibular disorders: a resting-state fMRI study.Journal of oral & facial pain and headache · 2026Article
- Neural mechanisms and neuromodulation therapies for non-suicidal self-injury.Molecular psychiatry · 2025Review
- Altered Grey Matter Volume and Cerebral Perfusion over the Whole Brain in Painful Temporomandibular Disorders: A Pilot Voxel-Based Analysis.Current medical imaging · 2025Article
- Disrupted Spontaneous Neural Activity and Its Interaction With Pain and Emotion in Temporomandibular Disorders.Frontiers in neuroscience · 2022Article
- Altered brain responses to noxious dentoalveolar stimuli in high-impact temporomandibular disorder pain patients.PloS one · 2022Article
- The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome.Frontiers in human neuroscience · 2022Article
- Abnormal static and dynamic brain function in patients with temporomandibular disorders: a resting-state functional magnetic resonance imaging study.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- Neural Pathways of Craniofacial Muscle Pain: Implications for Novel Treatments.Journal of dental research · 2020Review
- The Medial Thalamus Plays an Important Role in the Cognitive and Emotional Modulation of Orofacial Pain: A Functional Magnetic Resonance Imaging-Based Study.Frontiers in neurology · 2020Article
- Reduced corticostriatal functional connectivity in temporomandibular disorders.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although temporomandibular disorders (TMD) have been associated with abnormal gray matter volumes in cortical areas and in the striatum, the corticostriatal functional connectivity (FC) of patients with TMD has not been studied. Here, we studied 30 patients with TMD and 20 healthy controls that underwent clinical evaluations, including Helkimo indices, pain assessments, and resting-state functional magnetic resonance imaging scans. The FCs of the striatal regions with the other brain areas were examined with a seed-based approach. As seeds, we used the dorsal caudate, ventral caudate/nucleus accumbens, dorsal caudal putamen, and ventral rostral putamen regions. Voxel-wise comparisons with controls revealed that the patients with TMD exhibited reduced FCs in the ventral corticostriatal circuitry, between the ventral striatum and ventral frontal cortices, including the anterior cingulate cortex and anterior insula; in the dorsal corticostriatal circuitry, between the dorsal striatum and the dorsal cortices, including the precentral gyrus and supramarginal gyrus; and also within the striatum. Additionally, we explored correlations between the reduced corticostriatal FCs and clinical measurements. These results directly supported the hypothesis that TMD is associated with reduced FCs in brain corticostriatal networks and that these reduced FCs may underlie the deficits in motor control, pain processing, and cognition in TMD. Our findings may contribute to the understanding of the etiologies and pathologies of TMD.
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