Evidence map›Paper›PMID 29503969›Full record

ArticleOphthalmology. Retina2018

Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study.

Douglas A Stram, Xuejuan Jiang, Rohit Varma, Mina Torres, Bruce S Burkemper, Farzana Choudhury, Ronald Klein, W James Gauderman, Roberta McKean-Cowdin, Chinese American Eye Study Group

Open access · greenAbstract read
In one paragraph

Article in Ophthalmology. Retina, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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  5. Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Douglas A StramUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, California, United States.
Xuejuan JiangUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, California, United States.
Rohit VarmaUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, California, United States.
Mina TorresUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, California, United States.
Bruce S BurkemperUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, California, United States.
Farzana ChoudhuryUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, California, United States.
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
W James GaudermanDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, California, United States.
Roberta McKean-CowdinDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, California, United States.
Chinese American Eye Study Group
Southern California Eye Institute · USUniversity of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Chinese American Eye StudyU10EY017337 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 2009 to 2013
$10.2M
NEI NIH HHS U10 EY017337NIEHS NIH HHS P30 ES007048
6 · The paper itself

Abstract

objectiveTo identify factors associated with prevalent diabetic retinopathy (DR) among Chinese American adults with type 2 diabetes mellitus (T2DM), and to compare these factors to ones previously described for a population-based sample of Latinos with a higher DR prevalence.

designPopulation-based cross-sectional study.

participants4582 Chinese Americans aged 50 or older residing in Monterey Park, California.

methodsParticipants completed an in-home questionnaire on socio-demographic status and medical history, and a comprehensive clinical eye examination, using the same protocol implemented in the Los Angeles Latino Eye Study. Fundus photographs from 7 Early Treatment Diabetic Retinopathy fields were graded in a masked manner using a modified Airlie House grading system to assess presence and severity of DR. Logistic regression analyses based on a conceptual model of DR risk identified factors associated with prevalent DR.

main outcome measuresOdds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with DR and vision-threatening DR (VTDR).

resultsIn total, 238 participants were diagnosed with any DR; 27 of these were classified as having VTDR. Both, any DR and VTDR showed statistically significant positive associations with T2DM duration (OR

conclusionsWhile we observed an overall lower DR prevalence in Chinese Americans than in Latinos (35.8% of individuals with TD2M in Chinese Americans versus 42.0% in Latinos), our data indicate that the impact of increasing HbA1c and SBP on DR probability is incrementally the same in both populations. However, increasing T2DM duration is associated with higher DR probability in Latinos than Chinese Americans, even after controlling for other known predictors. Novel factors associated with VTDR include antihypertensive drugs and statins. However, to determine if these drugs impact VTDR susceptibility, we need longitudinal data and more cases.

Identifiers

PMID29503969
PMCPMC5828248
OpenAlexW2750469900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.