Evidence map›Paper›PMID 29503883›Full record

ArticleAmerican journal of ophthalmology case reports2016

Parafoveal cone abnormalities and recovery on adaptive optics in posterior uveitis.

Kristin Biggee, Michael J Gale, Travis B Smith, Eric B Suhler, Mark E Pennesi, Phoebe Lin

Open access · goldAbstract readCase Reports
In one paragraph

Article in American journal of ophthalmology case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Clinical Application of Adaptive Optics Imaging in Diagnosis, Management, and Monitoring of Ophthalmological Diseases: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kristin BiggeeKaiser Medical Group Salmon Creek, 14406 NE 20th Ave, Vancouver, WA 98686, USA.
Michael J GaleCasey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Travis B SmithCasey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Eric B SuhlerCasey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Mark E PennesiCasey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Phoebe LinCasey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USLegacy Salmon Creek Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine if adaptive optics (AO) flood illumination imaging can detect subclinical changes in 4 cases of posterior uveitis affecting the outer retina. OBSERVATIONS: In all 4 cases, the affected eye showed altered areas in the photoreceptor mosaic on AO that corresponded to changes on other imaging modalities. Abnormalities not apparent on other imaging modalities were also noted. In one case of multifocal choroiditis with acute outer retinal atrophy, AO revealed decreased visualization of photoreceptors in the unaffected eye that was not noted on spectral domain-optical coherence tomography. In the patient with multiple evanescent white dot syndrome, focal photoreceptor abnormalities were more apparent on AO compared to other imaging modalities, and these areas normalized on AO during follow-up. Five weeks after initiation of high dose prednisone and azathioprine in a patient with serpiginous choroidopathy, AO images showed recovery in apparent parafoveal cone density. CONCLUSIONS AND IMPORTANCE: AO detects subclinical changes in the photoreceptor layer in posterior uveitis that can recover over time. AO may be useful in following outer retinal inflammatory conditions.

Indexed as

Adaptive opticsAutofluorescenceOptical coherence tomographyPhotoreceptorsPosterior uveitis

Identifiers

PMID29503883
PMCPMC5757342
OpenAlexW2341802006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.