Evidence map›Paper›PMID 29503817›Full record

ArticleFrontiers in cell and developmental biology2018

Cystathionine β-Synthase Is Necessary for Axis Development

Shubhangi Prabhudesai, Chris Koceja, Anindya Dey, Shahram Eisa-Beygi, Noah R Leigh, Resham Bhattacharya, Priyabrata Mukherjee, Ramani Ramchandran

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Hydrogen sulfide and its role in female reproduction.Frontiers in veterinary science · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shubhangi PrabhudesaiDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Chris KocejaDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Anindya DeyDepartment of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, OK, United States.
Shahram Eisa-BeygiPediatrics Radiology, Developmental Vascular Biology Program, Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI, United States.
Noah R LeighMilwaukee Health Department, City of Milwaukee, Milwaukee, WI, United States.
Resham BhattacharyaDepartment of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, OK, United States.
Priyabrata MukherjeeDepartment of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, OK, United States.
Ramani RamchandranDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Medical College of Wisconsin · USUniversity of Oklahoma Health Sciences Center · USChildren's Hospital of Wisconsin · USMilwaukee Health Department · US

Funding

Molecular Mechanism of Antiangiogenic Properties of Gold NanoparticleR01CA136494 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MUKHERJEE, PRIYABRATA · 2009 to 2020
$2.9M
Targeting DUSP-5 to Treat Vascular AnomaliesR01HL112639 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2012 to 2016
$2.6M
Cystathionine beta synthase (CBS) and angiogenesisR01HL120585 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BHATTACHARYA, RESHAM, MUKHERJEE, PRIYABRATA · 2013 to 2017
$2.1M
Delta like-4 long non-coding RNA function in angiogenesis and vascular anomaliesR01HL123338 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2015 to 2018
$1.8M
Exploiting gold nanoparticle as a probe to identify therapeutic targetsR01CA260449 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Resham Bhattacharya, Priyabrata Mukherjee · 2022 to 2026
$1.6M
NCI NIH HHS R01 CA136494NCI NIH HHS R01 CA260449NHLBI NIH HHS R01 HL112639NHLBI NIH HHS R01 HL120585NHLBI NIH HHS R01 HL123338
6 · The paper itself

Abstract

The cystathionine ß-synthase (CBS) is a critical enzyme in the transsulfuration pathway and is responsible for the synthesis of cystathionine from serine and homocysteine. Cystathionine is a precursor to amino acid cysteine. CBS is also responsible for generation of hydrogen sulfide (H

Indexed as

CRISPRhomcystinuriahydrogen sulfidemethioninemorpholinosmall moleculeszebrafish

Identifiers

PMID29503817
PMCPMC5820354
OpenAlexW2793921592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.