ReviewFrontiers in pediatrics2018
The Pathophysiology of Low Systemic Blood Flow in the Preterm Infant.
Review in Frontiers in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07273643 (Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Comparative efficacy of volume expansion, inotropes and vasopressors in preterm neonates with probable transitional circulatory instability in the first week of life: a systematic review and network meta-analysis.BMJ paediatrics open · 2024Pooled it
- Trial
- Japan at the limits of viability: national experience and evolving outcomes of infants born at 22-23 weeks' gestation.Pediatric research · 2026Review
- Vasopressin for hemodynamic support in neonates: current evidence and clinical applications.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22-23weeks gestation.Frontiers in pediatrics · 2026Article
- Parenting experiences of informal caregivers of preterm infants during the first 2 years of life at corrected age: a qualitative systematic review protocol.JBI evidence synthesis · 2025Article
- Variability in the Deformability of Red Blood Cells: Application to Treating Premature Newborns with Blood Transfusion.International journal of molecular sciences · 2025Article
- Early echocardiographic predictors of death or early severe morbidity in extremely low gestational age neonates: a prospective study.European journal of pediatrics · 2025Observational
- Impact of a patent ductus arteriosus on non-invasive pre- and post-ductal blood pressures in extremely preterm infants during the first two postnatal weeks.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
- Forehead monitoring of heart rate in neonatal intensive care.Frontiers in physiology · 2023Article
- Echocardiographic Quantification of Superior Vena Cava (SVC) Flow in Neonates: Pilot Study of Modified Technique.Diagnostics (Basel, Switzerland) · 2022Article
- Value of bedside echocardiography in predicting persistent patency of the ductus arteriosus during the early postnatal period in very low birth weight infants.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment.Journal of clinical medicine · 2021Review
- The clinical effects of cerebral near-infrared spectroscopy monitoring (NIRS) versus no monitoring: a protocol for a systematic review with meta-analysis and trial sequential analysis.Systematic reviews · 2021Article
- The neonatal assessment manual score (NAME) for improving the clinical management of infants: a perspective validity study.Italian journal of pediatrics · 2021Article
- Intraventricular Hemorrhage in Very Preterm Infants: A Comprehensive Review.Journal of clinical medicine · 2020Review
- Neonatal Assessment Manual Score: Is There a Role of a Novel, Structured Touch-Based Evaluation in Neonatal Intensive Care Unit?Frontiers in pediatrics · 2020Article
- Is perfusion index a surrogate indicator of left ventricular contractility in neonates? A prospective study.Annals of pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assessment and treatment of the VLBW infant with cardiovascular impairment requires understanding of the underlying physiology of the infant in transition. The situation is dynamic with changes occurring in systemic blood pressure, pulmonary pressures, myocardial function, and ductal shunt in the first postnatal days. New insights into the role of umbilical cord clamping in the transitional circulation have been provided by large clinical trials of early versus later cord clamping and a series of basic science reports describing the physiology in an animal model. Ultrasound assessment is invaluable in assessment of the physiology of the transition and can provide information about the size and shunt direction of the ductus arteriosus, the function of the myocardium and its filling as well as measurements of the cardiac output and an estimate of the state of peripheral vascular resistance. This information not only allows more specific treatment but it will often reduce the need for treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.