ArticleCurrent addiction reports2017
Mechanisms Underlying Sex Differences in Cannabis Use.
Article in Current addiction reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis.CNS drugs · 2026Pooled it
- Cannabis use among Arab students: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Concurrent validity of the marijuana purchase task: a meta-analysis of trait-level cannabis demand and cannabis involvement.Addiction (Abingdon, England) · 2023Pooled it
- Age- and Sex-Related Cortical Gray Matter Volume Differences in Adolescent Cannabis Users: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in psychiatry · 2021Pooled it
- Mobile intervention to address cannabis use disorder among black adults: A proof-of-concept randomized controlled trial.Behaviour research and therapy · 2025Trial
- Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study.Psychopharmacology · 2024Trial
- Sex differences in the acute effects of smoked cannabis: evidence from a human laboratory study of young adults.Psychopharmacology · 2020Trial
- Patterns of Drug Use Across Social and Sexual Contexts in Spain: Insights From the European Web Survey on Drugs 2024.Archives of sexual behavior · 2026Article
- Investigating sex differences in the acute effects of smoked cannabis: a potency-ranging, controlled administration, human laboratory experiment.Psychopharmacology · 2026Article
- Prevalence, Associations and Comorbidity of Cannabis Use and Cannabis Use Disorders in the Australian National Mental Health Surveys From 2007 to 2020-22.Drug and alcohol review · 2026Article
- Cannabis use measurement: Identifying the optimal metric for broad research applications.Addiction (Abingdon, England) · 2026Observational
- School Belonging and Racial Mistreatment: Association With Substance Use Among U.S. High School Students.Journal of racial and ethnic health disparities · 2026Article
- Sex-specific behavioral and monoaminergic network alterations following adolescent binge-like ethanol and WIN55,212-2 exposure under chronic nicotine in rats.Frontiers in pharmacology · 2026Article
- Differential associations of mental health, mild traumatic brain injury and substance use between male and female university students.PloS one · 2026Article
- A two-factor structure for cannabis use disorder identification test and its associations with demographic factors and cannabis use motives.Advances in drug and alcohol research · 2026Article
- What Do Thirty Years of Neuroimaging Research Tell Us About Recreational Cannabis Use and Brain Integrity? A Narrative Review of the Multimodal Neuroimaging Evidence to Date.Substance abuse and rehabilitation · 2026Review
- Early Life Exposure to ΔCannabis and cannabinoid research · 2025Article
- Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms.JAACAP open · 2025Article
- Melanin-Concentrating Hormone (MCH): Role in Mediating Reward-Motivated and Emotional Behavior and the Behavioral Disturbances Produced by Repeated Exposure to Reward Substances.International journal of molecular sciences · 2025Review
- Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purpose of the reviewCannabis is the most commonly used illicit substance worldwide. In recent decades, highly concentrated products have flooded the market, and prevalence rates have increased. Gender differences exist in cannabis use, as men have higher prevalence of both cannabis use and cannabis use disorder (CUD), while women progress more rapidly from first use to CUD. This paper reviews findings from preclinical and human studies examining the sex-specific neurobiological underpinnings of cannabis use and CUD, and associations with psychiatric symptoms. RECENT
findingsSex differences exist in the endocannabinoid system, in cannabis exposure effects on brain structure and function, and in the co-occurrence of cannabis use with symptoms of anxiety, depression and schizophrenia. In female cannabis users, anxiety symptoms correlate with larger amygdala volume and social anxiety disorder symptoms correlate with CUD symptoms. Female cannabis users are reported to be especially vulnerable to earlier onset of schizophrenia, and mixed trends emerge in the correlation of depressive symptoms with cannabis exposure in females and males. SUMMARY: As prevalence of cannabis use may continue to increase given the shifting policy landscape regarding marijuana laws, understanding the neurobiological mechanisms of cannabis exposure in females and males is key. Examining these mechanisms may help inform future research on sex-specific pharmacological and behavioral interventions for women and men with high-risk cannabis use, comorbid psychiatric disease, and CUD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.