Evidence map›Paper›PMID 29503646›Full record

ArticleFrontiers in immunology2018

Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling

Sue-Jie Koo, Bartosz Szczesny, Xianxiu Wan, Nagireddy Putluri, Nisha Jain Garg

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. An Update on Vaccines AgainstPathogens (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Article
  8. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  9. Review
  10. Extracellular Vesicles Derived FromJournal of parasitology research · 2024
    Article
  11. Article
  12. iScience · 2023
    Article
  13. Review
  14. Article
  15. A Review on the Immunological Response againstPathogens (Basel, Switzerland) · 2023
    Review
  16. Cardiomyocyte infection byFrontiers in cellular and infection microbiology · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sue-Jie KooDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX, United States.
Bartosz SzczesnyDepartment of Anesthesiology, University of Texas Medical Branch (UTMB), Galveston, TX, United States.
Xianxiu WanDepartment of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX, United States.
Nagireddy PutluriDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX, United States.
Nisha Jain GargDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX, United States.
The University of Texas Medical Branch at Galveston · USBaylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Oxidative Response Networks in Chagasic CardiomyopathyR01AI136031 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Nisha Jain Garg · 2017 to 2026
$3.6M
Pathogenesis of Oxidative Stress in Chagasic MyocarditisR01AI054578 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI GARG, NISHA JAIN · 2005 to 2016
$3.3M
NCI NIH HHS P30 CA125123NIAID NIH HHS R01 AI054578NIAID NIH HHS R01 AI136031
6 · The paper itself

Abstract

Metabolism provides substrates for reactive oxygen species (ROS) and nitric oxide (NO) generation, which are a part of the macrophage (Mφ) anti-microbial response. Mφs infected with

Indexed as

AnimalsChagas CardiomyopathyDisease Models, AnimalHost-Parasite InteractionsHumansInterferon-gammaMacrophagesMiceMice, KnockoutNitric OxidePentose Phosphate PathwayPPAR alphaPrimary Cell CultureRAW 264.7 CellsReactive Oxygen SpeciesTrypanosoma cruziIFNG protein, mouseInterferon-gammaNitric OxidePPAR alphaReactive Oxygen SpeciesmacrophagesmetabolismNADPHpentose phosphate pathwayperoxisome proliferator-activated receptorsreactive oxygen speciesTrypanosoma cruzi

Identifiers

PMID29503646
PMCPMC5820298
OpenAlexW2797552543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.