ArticleOncoTargets and therapy2018
Prognostic significance of mucinous component in gastric adenocarcinoma after radical D2 gastrectomy.
Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Histopathological response to chemotherapy and survival of mucinous type gastric cancer.Journal of the National Cancer Institute · 2025Article
- Development and validation of a CT-based radiomics nomogram for preoperative prediction of tumor histologic grade in gastric adenocarcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021Article
- Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer.Canadian journal of gastroenterology & hepatology · 2021Article
- The clinicopathological characteristics and genetic alterations of mucinous carcinoma of the stomach.Journal of the Chinese Medical Association : JCMA · 2020Article
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8 authors.
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Abstract
backgroundThe mucinous component is a special histologic factor in gastric adenocarcinoma. The aim of this study was to assess the prognostic significance of mucinous component in gastric adenocarcinoma according to proportion. PATIENTS AND
methodsCandidate patients with gastric adenocarcinoma were given radical D2 gastrectomies from September 2008 to May 2015 in our division. Clinicopathologic data and prognosis were monitored and analyzed among gastric adenocarcinoma patients with various proportions of mucinous component.
resultsA total of 690 gastric adenocarcinomas with various proportions of mucinous component from 6,025 gastric adenocarcinoma patients were included. Higher numbers of patients with mucinous component came from: young patients, females, those with drinking history, at lower locations, Borrmann type III and IV, T4 stage, and positive for dissected lymph nodes. Tumors and pathological molecular markers showed more positivity in CEA, CA19-9, S100, and CD34. As the various proportions increased, more mucinous component seemed to be accompanied by more Borrmann type III and IV, T4 stage, and more positive expression of CEA and CA19-9. However, no significant difference in 5-year overall survival rate was observed among various proportions or existence of mucinous component. Also, proportion or existence of mucinous component was not an independent prognostic factor in multivariate analysis.
conclusionMucinous component was not a prognostic factor for gastric adenocarcinoma after radical D2 gastrectomy, no matter what proportion the component comprised. However, gastric adenocarcinoma with mucinous component showed specific clinicopathological characteristics, such as more advanced tumor stage, different age and sex, and more positive rate of molecular markers, which might provide a new strategy for optimal individual diagnosis and therapies.
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