Evidence map›Paper›PMID 29503547›Full record

ArticleNeuropsychiatric disease and treatment2018

Pediatric-onset multiple sclerosis in Egypt: a multi-center registry of 186 patients.

Sherif M Hamdy, Maged Abdel-Naseer, Nevin M Shalaby, Alaa Elmazny, Marian Girgis, Mona A Nada, Amr Hassan, Husam S Mourad, Mohamed I Hegazy, Ahmed Abdelalim and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Sherif M HamdyNeurology Department, Cairo University, Cairo, Egypt.
Maged Abdel-NaseerNeurology Department, Cairo University, Cairo, Egypt.
Nevin M ShalabyNeurology Department, Cairo University, Cairo, Egypt.
Alaa ElmaznyNeurology Department, Cairo University, Cairo, Egypt.
Marian GirgisPediatric Department, Cairo University, Cairo, Egypt.
Mona A NadaNeurology Department, Cairo University, Cairo, Egypt.
Amr HassanNeurology Department, Cairo University, Cairo, Egypt.
Husam S MouradNeurology Department, Cairo University, Cairo, Egypt.
Mohamed I HegazyNeurology Department, Cairo University, Cairo, Egypt.
Ahmed AbdelalimNeurology Department, Cairo University, Cairo, Egypt.
Nirmeen A KishkNeurology Department, Cairo University, Cairo, Egypt.
Noha T AbokryshaNeurology Department, Cairo University, Cairo, Egypt.
Shaimaa A GenedyNeurology Department, Cairo University, Cairo, Egypt.
Ehab A EssawyDivision of Biochemistry, Chemistry Department, Faculty of Science, Helwan University, Helwan, Egypt.
Hatem S ShehataNeurology Department, Cairo University, Cairo, Egypt.
Cairo University · EGHelwan University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough the frequency of pediatric-onset multiple sclerosis (POMS) has increased in recent decades, it is still highly uncommon, which creates a need for the involvement of more registries from various clinical centers.

objectiveTo characterize the demographic, clinical, and paraclinical features of Egyptian patients with POMS. PATIENTS AND

methodsA retrospective chart review study was undertaken on 237 Egyptian patients with demyelinating events which started before the age of 18 years who attended one of five tertiary referral centers in Cairo, Egypt.

resultsMultiple sclerosis was diagnosed in 186 patients, 47 (25.27%) patients had disease onset before the age of 12 years; "early-onset pediatric multiple sclerosis (EOPMS)". The mean age of disease onset was (14.13±2.49 years), with a female:male ratio of 1.62:1, none of the enrolled patients had a primary progressive course (PPMS), whereas 10 patients (5.38%) had a secondary progressive form. Approximately two-thirds of the patients had monofocal disease onset, and less than 10% presented with encephalopathy; most of them had EOPMS. Motor weakness was the presenting symptom in half of the patients, whereas cerebellar presentation was detected in 34.95%, mainly in EOPMS. Seizures (not related to encephalopathy) were more frequent in those with EOPMS. Initial brain magnetic resonance images were positive in all patients, with detected atypical lesions in 29.03%, enhanced lesions in 35.48%, black holes in 13.98%, and infratentorial in 34.41%. Cervical cord involvement was found in 68.28%. More than two-thirds of the patients received either immunomodulatory or immunosuppressant (IS) treatment throughout their disease course, and about half of them received their treatment within the first year from symptoms onset, with a more favorable outcome, and patients with highly active disease received natalizumab, fingolimod, or other IS.

conclusionThe results from this registry - the largest for MS in the Arab region to date - are comparable to other registries. Immunomodulatory therapies in POMS are well tolerated and efficacious and they can improve the long-term outcome in children.

Indexed as

early onsetEgyptmultiple sclerosispediatric onsetregistry

Identifiers

PMID29503547
PMCPMC5827680
OpenAlexW2793888151

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.