Evidence map›Paper›PMID 29503447›Full record

ArticleOncogene2018

LIN28B enhanced tumorigenesis in an autochthonous KRAS

Lydia Meder, Katharina König, Felix Dietlein, Iris Macheleidt, Alexandra Florin, Meryem S Ercanoglu, Ursula Rommerscheidt-Fuss, Mirjam Koker, Gisela Schön, Margarete Odenthal and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Lydia MederDepartment I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany. lydia.meder@uk-koeln.de.
Katharina KönigLabor Dr. Quade und Kollegen GmbH, Aachener Straße 338, Cologne, 50933, Germany.
Felix DietleinDepartment of Medical Oncology, Dana-Faber Cancer Institute, Boston, MA, 02215, USA.
Iris MacheleidtInstitute for Pathology, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany.
Alexandra FlorinInstitute for Pathology, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany.
Meryem S ErcanogluInstitute of Virology, Laboratory of Experimental Immunology, University of Cologne, Robert-Koch Straße 21, Cologne, 50931, Germany.
Ursula Rommerscheidt-FussInstitute for Pathology, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany.
Mirjam KokerDepartment I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany.
Gisela SchönDepartment I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany.
Margarete OdenthalCenter for Molecular Medicine Cologne, University of Cologne, Robert-Koch Straße 21, Cologne, 50931, Germany.
Florian KleinInstitute of Virology, Laboratory of Experimental Immunology, University of Cologne, Robert-Koch Straße 21, Cologne, 50931, Germany.
Reinhard BüttnerCenter for Molecular Medicine Cologne, University of Cologne, Robert-Koch Straße 21, Cologne, 50931, Germany.
Johannes H SchulteDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany.
Lukas C HeukampNew Oncology, Gottfried-Hagen-Straße 20, 51105, Cologne, Germany.
Roland T UllrichDepartment I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, Cologne, 50937, Germany.
University Hospital Cologne · DEUniversity of Cologne · DEBroad Institute · USDeutschen Konsortium für Translationale Krebsforschung · DEInstitut für Hämatopathologie Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer. LIN28B expression is associated with tumor initiation, progression, resistance, and poor outcome in several solid cancers, including lung cancer. However, the functional role of LIN28B, especially in non-small cell lung adenocarcinomas, remains elusive. Here, we investigated the effects of LIN28B expression on lung tumorigenesis using LIN28B transgenic overexpression in an autochthonous KRAS

Indexed as

MutationAnimalsCarcinoma, Non-Small-Cell LungEpithelial Cell Adhesion MoleculeEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansHyaluronan ReceptorsLung NeoplasmsMiceMice, TransgenicNeoplasms, ExperimentalProto-Oncogene Proteins p21(ras)RNA-Binding ProteinsSurvival AnalysisCD44 protein, humanEpithelial Cell Adhesion MoleculeHyaluronan ReceptorsKRAS protein, humanLIN28B protein, humanProto-Oncogene Proteins p21(ras)RNA-Binding Proteins

Identifiers

PMID29503447
OpenAlexW2792954905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.