Evidence map›Paper›PMID 29503411›Full record

ArticleJournal of atherosclerosis and thrombosis2018

Low Levels of Plasma Osteoglycin in Patients with Complex Coronary Lesions.

Toshiki Seki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Yoshichika Miyazaki, Kotaro Miura, Reiko Ohmori, Yukinori Ikegami, Kazuo Kondo, Yukihiko Momiyama

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Proteomic Studies of Blood and Vascular Wall in Atherosclerosis.International journal of molecular sciences · 2021
    Review
  3. Article
  4. Article
  5. High Plasma Levels of Legumain in Patients with Complex Coronary Lesions.Journal of atherosclerosis and thrombosis · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Toshiki SekiDepartment of Cardiology, National Hospital Organization Tokyo Medical Center.
Emi SaitaEndowed Research Department "Food for Health", Ochanomizu University.
Yoshimi KishimotoEndowed Research Department "Food for Health", Ochanomizu University.
Susumu IbeDepartment of Cardiology, National Hospital Organization Tokyo Medical Center.
Yoshichika MiyazakiDepartment of Cardiology, National Hospital Organization Tokyo Medical Center.
Kotaro MiuraDepartment of Cardiology, National Hospital Organization Tokyo Medical Center.
Reiko OhmoriFaculty of Regional Design, Utsunomiya University.
Yukinori IkegamiDepartment of Cardiology, National Hospital Organization Tokyo Medical Center.
Kazuo KondoEndowed Research Department "Food for Health", Ochanomizu University.
Yukihiko MomiyamaDepartment of Cardiology, National Hospital Organization Tokyo Medical Center.
National Hospital Organization · JPOchanomizu University · JPTokyo Medical Center · JPToyo University · JPUtsunomiya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimOsteoglycin is one of proteoglycans that are biologically active components of vascular extracellular matrix. However, the role of osteoglycin in atherosclerosis remains unclear.

methodsWe investigated plasma osteoglycin levels and the presence, severity, and lesion morphology of coronary artery disease (CAD) in 462 patients undergoing elective coronary angiography.

resultsOf 462 patients, 245 had CAD. Osteoglycin levels were higher in patients with CAD than without CAD (median 29.7 vs. 25.0 ng/mL, P＜0.05). However, osteoglycin levels did not differ among patients with one-vessel, two-vessel, or three-vessel disease (30.8, 30.6, and 29.4 ng/mL, respectively) and did not correlate with the number of stenotic segments. Among 245 CAD patients, 41 had complex coronary lesions, and 70 had total occlusion, of whom 67 had good collateralization. Between 70 patients with occlusion and 175 without occlusion, osteoglycin levels did not differ (30.4 vs. 29.5 ng/mL). Notably, osteoglycin levels were lower in 41 patients with complex lesions than in 204 without such lesions (24.2 vs. 31.6 ng/mL, P＜0.02). In multivariate analysis, osteoglycin levels were an independent factor for complex lesion but not for CAD. Odds ratio for complex lesion was 0.80 (95%CI=0.67-0.96) for each 10 ng/mL increase in osteoglycin levels (P＜0.02).

conclusionAlthough plasma osteoglycin levels were high in patients with CAD, they did not correlate with the severity of CAD and were not an independent factor for CAD. Notably, osteoglycin levels were low in patients with complex lesions and were a factor for complex lesions, suggesting that osteoglycin plays a role in coronary plaque stabilization.

Indexed as

Severity of Illness IndexAgedBiomarkersCase-Control StudiesCoronary AngiographyCoronary Artery DiseaseFemaleFollow-Up StudiesHumansIntercellular Signaling Peptides and ProteinsMalePrognosisRisk FactorsBiomarkersIntercellular Signaling Peptides and ProteinsOGN protein, humanCoronary artery diseaseOsteoglycinPlaque stabilization

Identifiers

PMID29503411
PMCPMC6224206
OpenAlexW2789699870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.