Evidence map›Paper›PMID 29503225›Full record

ArticleEBioMedicine2018

Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.

Giulia Fregni, Mathieu Quinodoz, Emely Möller, Joanna Vuille, Sabine Galland, Carlo Fusco, Patricia Martin, Igor Letovanec, Paolo Provero, Carlo Rivolta and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  12. Mesenchymal Stem Cells in Cancer Therapy.Advances in experimental medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Giulia FregniExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Mathieu QuinodozDepartment of Computational Biology, Unit of Medical Genetics, University of Lausanne, 1011, Switzerland.
Emely MöllerExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Joanna VuilleExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Sabine GallandExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Carlo FuscoExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Patricia MartinExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Igor LetovanecExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Paolo ProveroCenter for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, IRCCS, Milan20132, Italy; Dept. of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
Carlo RivoltaDepartment of Computational Biology, Unit of Medical Genetics, University of Lausanne, 1011, Switzerland; Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 9HN, UK.
Nicolo RiggiExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland.
Ivan StamenkovicExperimental Pathology Service, CHUV and University of Lausanne, 1011, Switzerland. Electronic address: Ivan.Stamenkovic@chuv.ch.
University of Lausanne · CHUniversity of Leicester · GBVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis is a multi-step process in which direct crosstalk between cancer cells and their microenvironment plays a key role. Here, we assessed the effect of paired tumor-associated and normal lung tissue mesenchymal stem cells (MSCs) on the growth and dissemination of primary human lung carcinoma cells isolated from the same patients. We show that the tumor microenvironment modulates MSC gene expression and identify a four-gene MSC signature that is functionally implicated in promoting metastasis. We also demonstrate that tumor-associated MSCs induce the expression of genes associated with an aggressive phenotype in primary lung cancer cells and selectively promote their dissemination rather than local growth. Our observations provide insight into mechanisms by which the stroma promotes lung cancer metastasis.

Indexed as

Cell CommunicationTumor MicroenvironmentAgedAged, 80 and overAnimalsBiomarkersDisease Models, AnimalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLung NeoplasmsMaleMesenchymal Stem CellsMiceMiddle AgedBiomarkersADAMTS12GREM1ITGA11LOXL2lung cancermetastasisTumor-associated MSCs

Identifiers

PMID29503225
PMCPMC5925622
OpenAlexW2792755886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.