Evidence map›Paper›PMID 29503087›Full record

ArticleStem cell reports2018

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control.

Thomas Robert, Ines De Mesmaeker, Geert M Stangé, Krista G Suenens, Zhidong Ling, Evert J Kroon, Daniel G Pipeleers

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 78 citations in OpenAlex.

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  13. A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion.Proceedings of the National Academy of Sciences of the United States of America · 2021
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  18. A Stem Cell Approach to Cure Type 1 Diabetes.Cold Spring Harbor perspectives in biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Thomas RobertDiabetes Research Center, Brussels Free University-VUB and University Hospital Brussels-UZB, Brussels 1090, Belgium; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium.
Ines De MesmaekerDiabetes Research Center, Brussels Free University-VUB and University Hospital Brussels-UZB, Brussels 1090, Belgium; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium.
Geert M StangéDiabetes Research Center, Brussels Free University-VUB and University Hospital Brussels-UZB, Brussels 1090, Belgium; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium.
Krista G SuenensDiabetes Research Center, Brussels Free University-VUB and University Hospital Brussels-UZB, Brussels 1090, Belgium; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium.
Zhidong LingDiabetes Research Center, Brussels Free University-VUB and University Hospital Brussels-UZB, Brussels 1090, Belgium; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium.
Evert J KroonViaCyte, Inc., San Diego, CA 92121, USA; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium.
Daniel G PipeleersDiabetes Research Center, Brussels Free University-VUB and University Hospital Brussels-UZB, Brussels 1090, Belgium; BetaCellTherapy Consortium (supported by EU and JDRF), Brussels, Belgium. Electronic address: daniel.pipeleers@vub.ac.be.
Center for Beta Cell Therapy in Diabetes · BEViaCyte (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human stem cells represent a potential source for implants that replace the depleted functional beta cell mass (FBM) in diabetes patients. Human embryonic stem cell-derived pancreatic endoderm (hES-PE) can generate implants with glucose-responsive beta cells capable of reducing hyperglycemia in mice. This study with device-encapsulated hES-PE (4 × 10

Indexed as

AnimalsCell LineEmbryonic Stem CellsEndodermGlucoseHomeodomain ProteinsHumansInsulin-Secreting CellsMaf Transcription Factors, LargeMiceMice, Inbred NODMice, SCIDTrans-ActivatorsGlucoseHomeodomain ProteinsMaf Transcription Factors, Largepancreatic and duodenal homeobox 1 proteinTrans-Activatorsdiabetesdifferentiationencapsulationfunctional beta cell massfunctional maturationmetabolic controlstem cell-derived pancreatic endodermstem cell therapy

Identifiers

PMID29503087
PMCPMC5918665
OpenAlexW2791583455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.