Evidence map›Paper›PMID 29502857›Full record

ArticleAmerican journal of surgery2018

Stratifying SLN incidence in intermediate thickness melanoma patients.

James M Chang, Heidi E Kosiorek, Amylou C Dueck, Stanley P L Leong, John T Vetto, Richard L White, Eli Avisar, Vernon K Sondak, Jane L Messina, Jonathan S Zager and 3 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in American journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

James M ChangDepartment of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Heidi E KosiorekSection of Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, USA.
Amylou C DueckSection of Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, USA.
Stanley P L LeongCenter for Melanoma Research and Treatment, Department of Surgery, California Pacific Medical Center, San Francisco, CA, USA.
John T VettoDepartment of Surgery, Oregon Health & Science University, Portland, OR, USA.
Richard L WhiteDepartment of Surgery, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC, USA.
Eli AvisarSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Vernon K SondakDepartments of Cutaneous Oncology and Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
Jane L MessinaDepartments of Cutaneous Oncology and Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
Jonathan S ZagerDepartments of Cutaneous Oncology and Sarcoma, Moffitt Cancer Center, Tampa, FL, USA.
Carlos GarberoglioDepartment of Surgery, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Mohammed Kashani-SabetCenter for Melanoma Research and Treatment, Department of Surgery, California Pacific Medical Center, San Francisco, CA, USA.
Barbara A PockajDepartment of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA. Electronic address: pockaj.barbara@mayo.edu.
Moffitt Cancer Center · USCalifornia Pacific Medical Center · USWinnMed · USCarolinas Medical Center · USLoma Linda University · USMayo Clinic Hospital · USMayo Clinic in Arizona · USOregon Health & Science University · USUniversity of Miami · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundGuidelines for melanoma recommend sentinel lymph node biopsy (SLNB) in patients with melanomas ≥1 mm thickness. Recent single institution studies have found tumors <1.5 mm a low-risk group for positive SLNB.

methodsA retrospective review of the Sentinel Lymph Node Working Group multicenter database identified patients with intermediate thickness melanoma (1.01-4.00 mm) who had SLNB, and assessed predictors for positive SLNB.

results3460 patients were analyzed, 584 (17%) had a positive SLNB. Univariate factors associated with a positive SLNB included age <60 (p < .001), tumor on the trunk/lower extremity (p < .001), Breslow depth ≥2 mm (p < .001), ulceration (p < .001), mitotic rate ≥1/mm

conclusionsIntermediate thickness melanoma has significant heterogeneity of SLNB positivity. Low-risk subgroups can be found among older patients in the absence of high-risk features.

Indexed as

AgedDatabases, FactualFemaleHumansIncidenceLymphatic MetastasisMaleMelanomaMiddle AgedRetrospective StudiesRisk FactorsSentinel Lymph NodeSentinel Lymph Node BiopsySkin Neoplasms

Identifiers

PMID29502857
PMCPMC5978691
OpenAlexW2772025297

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.