Evidence map›Paper›PMID 29502483›Full record

ArticleJournal of clinical and experimental neuropsychology2018

Recurrent perseverations on semantic verbal fluency tasks as an early marker of cognitive impairment.

Serguei V S Pakhomov, Lynn E Eberly, David S Knopman

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  9. Assessing within-task verbal fluency performance: the utility of individual time intervals in predicting incident mild cognitive impairment.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Serguei V S Pakhomova College of Pharmacy , University of Minnesota , Minneapolis , MN , USA.
Lynn E Eberlyb Division of Biostatistics , University of Minnesota , Minneapolis , MN , USA.
David S Knopmanc Department of Neurology , Mayo Clinic , Rochester , MN , USA.
University of Minnesota · USMayo Clinic in Arizona · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
NIA NIH HHS P50 AG016574NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

introductionOur objective was to examine the association between perseverations produced on the semantic verbal fluency (SVF) task in asymptomatic individuals and the future diagnosis of cognitive impairment (CI).

methodParticipants were individuals participating in the Mayo Clinic Study of Aging (N = 1269, M

resultsPerseverations on the "animals" SVF task were associated with incident CI (hazard ratio = 1.35; 95% confidence interval, CI [1.10, 1.66]). No significant association was found with perseverations on the "fruits" or "vegetables" SVF tasks. Mixed-effects modeling in cognitively normal participants revealed that the number of perseverations at baseline is significantly associated with decline in memory and visuospatial cognitive domains but is not associated with decline in attention.

conclusionsAssessing perseverations together with standard SVF scores on the "animals" SVF task can help in early identification of asymptomatic individuals at an increased risk for CI. Perseverations are not associated with attention, but rather visual and verbal working memory mechanisms. In longitudinal settings aimed at early detection of signs of CI in presymptomatic individuals, SVF testing with scoring that includes counting of perseverations may potentially serve as a practical alternative to the more cumbersome memory tests.

Indexed as

Neuropsychological TestsSemanticsAgedAged, 80 and overAttentionCognitive DysfunctionCohort StudiesFemaleHumansLongitudinal StudiesMaleMemory DisordersSpace PerceptionAlzheimer’s diseasecognitive impairmentdementiaperseverationsverbal fluency

Identifiers

PMID29502483
PMCPMC6338072
OpenAlexW2793413315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.