Evidence map›Paper›PMID 29502160›Full record

Trial reportLasers in medical science2018

Evaluation of laser therapy and alpha-lipoic acid for the treatment of burning mouth syndrome: a randomized clinical trial.

Natália Guimarães Barbosa, Amanda Katarinny Goes Gonzaga, Luzia Leiros de Sena Fernandes, Aldilane Gonçalves da Fonseca, Salomão Israel Monteiro Lourenço Queiroz, Telma Maria Araújo Moura Lemos, Éricka Janine Dantas da Silveira, Ana Miryam Costa de Medeiros

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 9 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 9 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Natália Guimarães BarbosaPostgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Amanda Katarinny Goes GonzagaPostgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil. amandaggonzaga@gmail.com.
Luzia Leiros de Sena FernandesPostgraduate Program in Technological Development and Innovation in Medicines, Federal University of Rio Grande do Norte, Natal, Brazil.
Aldilane Gonçalves da FonsecaPostgraduate Program in Technological Development and Innovation in Medicines, Federal University of Rio Grande do Norte, Natal, Brazil.
Salomão Israel Monteiro Lourenço QueirozPostgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Telma Maria Araújo Moura LemosPostgraduate Program in Technological Development and Innovation in Medicines, Federal University of Rio Grande do Norte, Natal, Brazil.
Éricka Janine Dantas da SilveiraPostgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Ana Miryam Costa de MedeirosPostgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Universidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the efficacy of low-level laser therapy (LLLT) and alpha-lipoic acid (ALA) in the treatment of burning mouth syndrome (BMS) and secondary oral burning (SOB) by unstimulated sialometry, symptom assessment, and measurement of salivary TNF-α levels. Forty-four patients were randomized into four treatment groups: BMS/laser (n = 10), BMS/ALA (n = 5), SOB/laser (n = 15), and SOB/ALA (n = 14). The control group consisted of eight healthy female subjects. Unstimulated salivary flow was measured before and after treatment, and the collected saliva was stored at - 20 °C for the analysis of TNF-α. Symptoms were evaluated before and after treatment using a pain visual analog scale. Most patients were women (81.8%) during menopause (72.2%). LLLT and ALA were efficient in increasing salivary flow only in BMS but provided symptom relief in both conditions. TNF-α levels did not differ between patients with BMS and SOB or between those patients and the control group. No differences were observed in posttreatment TNF-α levels in either condition. The results of this study suggest that LLLT and ALA are efficient therapies in reducing burning mouth symptoms, with LLLT being more efficient than ALA.

Indexed as

Low-Level Light TherapyBurning Mouth SyndromeCombined Modality TherapyFemaleHumansMaleMiddle AgedPain MeasurementSalivaThioctic AcidTumor Necrosis Factor-alphaVisual Analog ScaleThioctic AcidTumor Necrosis Factor-alphaBurning mouth syndromeDiagnosisLow-level laser therapySalivationTumor necrosis factor alpha

Identifiers

PMID29502160
OpenAlexW2791507860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.