Evidence map›Paper›PMID 29502085›Full record

Observational studyBMJ open2018

Prevalence of coronary artery calcification in a non-specific chest pain population in emergency and cardiology departments compared with the background population: a prospective cohort study in Southern Denmark with 12-month follow-up of cardiac endpoints.

Nivethitha Ilangkovan, Christian Backer Mogensen, Hans Mickley, Annmarie Touborg Lassen, Jess Lambrechtsen, Niels Peter Ronnow Sand, Rasmus Albiniussen, Jørgen Byg, Flemming Hald Steffensen, Mette Hjortdal Grønhøj and 1 more

Erratum issued Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02422316 (Non-contrast Cardiac CT as a Risk Stratification Tool in Patients With Non-cardiac Chest Pain), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02422316 completednot on this map

Non-contrast Cardiac CT as a Risk Stratification Tool in Patients With Non-cardiac Chest Pain

TypeobservationalSponsorUniversity of Southern DenmarkRan2014 to 2015Enrolled248ConditionsCoronary Artery DiseaseArmsNon-contrast Cardiac CT scan
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Nivethitha IlangkovanCardiology Department, Hospital of Southern Denmark, Aabenraa, Denmark.ORCID 0000-0002-1759-7590
Christian Backer MogensenEmergency Department, Hospital of Southern Denmark, Aabenraa, Denmark.ORCID 0000-0002-8254-089X
Hans MickleyCardiology Department, Odense University Hospital, Odense, Denmark.
Annmarie Touborg LassenEmergency Department, Odense University Hospital, Odense, Denmark.
Jess LambrechtsenMedical Department, Svendborg Hospital, Svendborg, Denmark.
Niels Peter Ronnow SandCardiology Department, Esbjerg Hiospital, Esbjerg, Denmark.
Rasmus AlbiniussenCardiology Department, Hospital of Southern Denmark, Aabenraa, Denmark.
Jørgen BygCardiology Department, Hospital of Southern Denmark, Aabenraa, Denmark.
Flemming Hald SteffensenCardiology Department, Vejle Hospital, Vejle, Denmark.
Mette Hjortdal GrønhøjCardiology Department, Odense University Hospital, Odense, Denmark.
Axel DiederichsenCardiology Department, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-1285-4826
Odense University Hospital · DKRegion of Southern Denmark · DKSvendborg Sygehus · DKVejle Sygehus · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine and compare the prevalence of coronary artery calcification (CAC) and the frequency of cardiac events in a background population and a cohort of patients with non-specific chest pain (NSCP) who present to an emergency or cardiology department and are discharged without an obvious reason for their symptom.

designA double-blinded, prospective, observational cohort study that measures both CT-determined CAC scores and cardiac events after 1 year of follow-up.

settingEmergency and cardiology departments in the Region of Southern Denmark. SUBJECTS: In total, 229 patients with NSCP were compared with 722 patients from a background comparator population. MAIN OUTCOMES MEASURES: Prevalence of CAC and incidence of unstable angina (UAP), acute myocardial infarction (MI), ventricular tachycardia (VT), coronary revascularisation and cardiac-related mortality 1 year after index contact.

resultsThere was no significant difference in the prevalence of CAC (OR 0.9 (95% CI 0.6 to 1.3), P=0.546) or the frequency of cardiac endpoints (P=0.64) between the studied groups. When compared with the background population, the OR for patients with NSCP for a CAC >100 Agatston units (AU) was 1.0 (95% CI 0.6 to 1.5), P=0.826. During 1 year of follow-up, two (0.9%) patients with NSCP underwent cardiac revascularisation, while none experienced UAP, MI, VT or death. In the background population, four (0.6%) participants experienced a clinical cardiac endpoint; two had an MI, one had VT and one had a cardiac-related death.

conclusionThe prevalence of CAC (CAC >0 AU) among patients with NSCP is comparable to a background population and there is a low risk of a cardiac event in the first year after discharge. A CAC study does not provide notable clinical utility for risk-stratifying patients with NSCP. TRIAL REGISTRATION NUMBER: NCT02422316; Pre-results.

Indexed as

AdultAgedAngina, UnstableCardiac Care FacilitiesChest PainComorbidityCoronary Artery DiseaseCoronary VesselsDenmarkDouble-Blind MethodEmergency Service, HospitalFemaleFollow-Up StudiesHumansIncidenceLogistic Modelscardiovascular imagingcomputed tomographycoronary heart diseasecoronary interventionischaemic heart diseasemyocardial infarction

Identifiers

PMID29502085
PMCPMC5855253
OpenAlexW2791413764

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.