Evidence map›Paper›PMID 29501970›Full record

ArticleBiomaterials2018

Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy.

Cheng Xu, Feng Chen, Hector F Valdovinos, Dawei Jiang, Shreya Goel, Bo Yu, Haiyan Sun, Todd E Barnhart, James J Moon, Weibo Cai

Abstract read
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 148 citations in OpenAlex.

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  11. Black phosphorus-incorporated novel Ti-12Mo-10Zr implant for multimodal treatment of osteosarcoma.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
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  12. Review
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  17. STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  18. Review
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  20. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cheng XuDepartment of Radiology, University of Wisconsin-Madison, WI 53705, United States.
Feng ChenDepartment of Radiology, University of Wisconsin-Madison, WI 53705, United States.
Hector F ValdovinosDepartment of Medical Physics, University of Wisconsin-Madison, WI 53705, United States.
Dawei JiangDepartment of Radiology, University of Wisconsin-Madison, WI 53705, United States.
Shreya GoelDepartment of Materials Science and Engineering, University of Wisconsin-Madison, WI 53706, United States.
Bo YuDepartment of Radiology, University of Wisconsin-Madison, WI 53705, United States.
Haiyan SunDepartment of Radiology, University of Wisconsin-Madison, WI 53705, United States.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison, WI 53705, United States.
James J MoonDepartment of Pharmaceutical Science, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States.
Weibo CaiDepartment of Radiology, University of Wisconsin-Madison, WI 53705, United States; Department of Medical Physics, University of Wisconsin-Madison, WI 53705, United States; Department of Materials Science and Engineering, University of Wisconsin-Madison, WI 53706, United States; University of Wisconsin Carbone Cancer Center, Madison, WI 53705, United States. Electronic address: wcai@uwhealth.org.
University of Wisconsin–Madison · USUniversity of Michigan–Ann Arbor · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneityR01CA205101 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SKALA, MELISSA CAROLINE · 2016 to 2020
$1.9M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Ultrasonic and Photoacoustic Imaging System for Cancer & Cardiovascular ResearchS10OD018505 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2015 to 2015
$908k
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS R01 CA205101NIBIB NIH HHS R01 EB021336NIH HHS S10 OD018505
6 · The paper itself

Abstract

Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. However, limited drug loading capacity and low tumor accumulation rate in vivo are two major challenges for the biomedical applications of MSN-coated GNRs (GNR@MSN). In this study, by coating uniformly sized GNRs with MSN in an oil-water biphase reaction system, we have successfully synthesized a new bacteria-like GNR@MSN (i.e., bGNR@MSN) with a significantly enlarged pore size (4-8 nm) and surface area (470 m

Indexed as

GoldNanotubesSilicon DioxideAnimalsAntineoplastic AgentsContrast MediaDoxorubicinDrug CarriersMiceMultimodal ImagingNeoplasms, ExperimentalPhotoacoustic TechniquesPhototherapyAntineoplastic AgentsContrast MediaDoxorubicinDrug CarriersGoldSilicon DioxideCancerChemo-photothermal therapyGold nanorodsMesoporous silica nanoparticlesPositron emission tomographyTheranostics

Identifiers

PMID29501970
PMCPMC5880312
OpenAlexW2792277560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.