ArticleNeurobiology of aging2018
Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Muscle bursting and corticomotor excitability mark impaired impulse control in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- The Aggregation ofBiomedicines · 2024Article
- Altered regional neural activity and functional connectivity in patients with non-communicating hydrocephalus: a resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2024Article
- Effect of dopamine on limbic network connectivity at rest in Parkinson's disease patients with freezing of gait.Translational neuroscience · 2024Article
- Effects of dopaminergic treatment on inhibitory control differ across Hoehn and Yahr stages of Parkinson's disease.Brain communications · 2024Article
- Towards Conceptual Clarification of Proactive Inhibitory Control: A Review.Brain sciences · 2022Review
- Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus.Neuroscience bulletin · 2022Review
- Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic 'hyperdirect' pathway in Parkinson's disease.NeuroImage. Clinical · 2022Article
- Relating Response Inhibition, Brain Connectivity, and Freezing of Gait in People with Parkinson's Disease.Journal of the International Neuropsychological Society : JINS · 2021Article
- Cognitive impairment and levodopa induced dyskinesia in Parkinson's disease: a longitudinal study from the PACOS cohort.Scientific reports · 2021Article
- Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson's Disease With Subthalamic Microlesion.Frontiers in neuroscience · 2021Article
- Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson's Disease with Freezing of Gait.Neural plasticity · 2020Article
- Akinetic rigid symptoms are associated with decline in a cortical motor network in Parkinson's disease.NPJ Parkinson's disease · 2020Article
- Levodopa Changes Functional Connectivity Patterns in Subregions of the Primary Motor Cortex in Patients With Parkinson's Disease.Frontiers in neuroscience · 2020Article
- Article
- Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.Frontiers in neurology · 2019Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Dopaminergic medications improve the motor symptoms of Parkinson's disease (PD), but their effect on response inhibition, a critical executive function, remains unclear. Previous studies primarily enrolled patients in more advanced stages of PD, when dopaminergic medication loses efficacy, and patients were typically on multiple medications. Here, we recruited 21 patients in early-stage PD on levodopa monotherapy and 37 age-matched controls to perform the stop-signal task during functional magnetic resonance imaging. In contrast to previous studies reporting null effects in more advanced PD, levodopa significantly improved response inhibition performance in our sample. No significant group differences were found in brain activations to pure motor inhibition or error processing (stop success vs. error trials). However, relative to controls, the PD group showed weaker striatal activations to salient events (infrequent vs. frequent events: stop vs. go trials) and fronto-striatal task-residual functional connectivity; both were restored with levodopa. Thus, levodopa appears to improve an important executive function in early-stage PD via enhanced salient signal processing, shedding new light on the role of dopaminergic signaling in response inhibition.
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