Evidence map›Paper›PMID 29501722›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2018

Supramolecular self assembly of nanodrill-like structures for intracellular delivery.

N Ashwanikumar, Justin S Plaut, Barmak Mostofian, Siddharth Patel, Peter Kwak, Conroy Sun, Kerry McPhail, Daniel M Zuckerman, Sadik C Esener, Gaurav Sahay

Open access · greenAbstract read
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

N AshwanikumarDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Justin S PlautCEDAR, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, United States; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, United States.
Barmak MostofianDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97201, United States.
Siddharth PatelDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Peter KwakDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Conroy SunDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States; Department of Radiation Medicine, School of Medicine, Oregon Health and Science University, Portland, OR 97239, United States.
Kerry McPhailDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Daniel M ZuckermanDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97201, United States.
Sadik C EsenerCEDAR, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, United States.
Gaurav SahayDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97201, United States. Electronic address: sahay@ohsu.edu.
Oregon State University · USOregon Health & Science University · US

Funding

Synergistic combination of nanotechnology and radiation in medicineR35GM119839 · NIGMS · OREGON STATE UNIVERSITY · PI SUN, CONROY GHIN CHEE · 2016 to 2020
$1.8M
Mechanisms of Intracellular trafficking and endosomal escape of nanoparticles for mRNA deliveryR15EB021581 · NIBIB · OREGON STATE UNIVERSITY · PI SAHAY, GAURAV · 2017 to 2017
$441k
NIBIB NIH HHS R15 EB021581NIGMS NIH HHS R35 GM119839
6 · The paper itself

Abstract

Despite recent advances in the supramolecular assembly of cell-penetrating peptide (CPP) nanostructures, the tuning of size, shape, morphology and packaging of drugs in these materials still remain unexplored. Herein, through sequential ligation of peptide building blocks, we create cell-penetrating self-assembling peptide nanomaterials (CSPNs) with the capability to translocate inside cells. We devised a triblock array of Tat

Indexed as

Cell-Penetrating PeptidesDrug CarriersDrug Delivery SystemsHeLa CellsHumansMicroscopy, Atomic ForceMolecular Dynamics SimulationNanostructuresPhenylalanineProtein Structure, Secondarytat Gene Products, Human Immunodeficiency VirusCell-Penetrating PeptidesDrug CarriersPhenylalaninetat Gene Products, Human Immunodeficiency VirusCell penetrating peptidesIntracellular deliveryNanodrillsSupramolecular assembly

Identifiers

PMID29501722
PMCPMC6008205
OpenAlexW2794019877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.