Evidence map›Paper›PMID 29501609›Full record

ArticleBiochimica et biophysica acta. Biomembranes2018

Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers.

Sarah E D Nelson, Kim N Ha, Tata Gopinath, Mara H Exline, Alessandro Mascioni, David D Thomas, Gianluigi Veglia

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Genetic landscape of phospholamban cardiomyopathies.Frontiers in cell and developmental biology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Intrinsically disordered HAX-1 regulates CaBiochimica et biophysica acta. Biomembranes · 2020
    Article
  8. TScientific reports · 2019
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sarah E D NelsonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States.
Kim N HaSt. Catherine University, Department of Chemistry and Biochemistry, 2004 Randolph Ave., St. Paul, MN 55105, United States.
Tata GopinathDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States.
Mara H ExlineSt. Catherine University, Department of Chemistry and Biochemistry, 2004 Randolph Ave., St. Paul, MN 55105, United States.
Alessandro MascioniDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, United States.
David D ThomasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States.
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: vegli001@umn.edu.
University of Minnesota · USSt. Catherine University · US

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Structural Dynamics of Muscle Calcium ATPase RegulationR01GM027906 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 1985 to 2016
$8.6M
NMR Structural Analysis of Calcium Regulation in MuscleR01GM064742 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VEGLIA, GIANLUIGI · 2002 to 2019
$7.1M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
Structural Basis Of Dilated CardiomyopathyR01GM072701 · NIGMS · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2007 to 2015
$2.4M
Protein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2M
Structural Basis of Dilated CardiomyopathyR01HL144130 · NHLBI · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2018 to 2021
$1.5M
Console Upgrade for a 600 MHz NMR SpectrometerS10OD021536 · OD · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2016 to 2016
$850k
Rational Design of Loss-of-Function Phospholamban Mutants for Gene TherapyF31HL095361 · NHLBI · UNIVERSITY OF MINNESOTA · PI HA, KIM N · 2009 to 2011
$90k
NHLBI NIH HHS F31 HL095361NHLBI NIH HHS R01 HL144130NIAMS NIH HHS T32 AR007612NIA NIH HHS R01 AG026160NIA NIH HHS R37 AG026160NIGMS NIH HHS R01 GM027906NIGMS NIH HHS R01 GM064742NIGMS NIH HHS R01 GM072701NIH HHS S10 OD021536
6 · The paper itself

Abstract

Approximately, 70% of the Ca

Indexed as

Amino Acid SubstitutionMutation, MissensePoint MutationAmino Acid SequenceCalcium-Binding ProteinsCardiomyopathy, DilatedConsensus SequenceHumansLipid BilayersMembrane ProteinsNuclear Magnetic Resonance, BiomolecularPhospholambanProtein ConformationProtein DomainsProtein Structure, SecondaryRecombinant ProteinsCalcium-Binding ProteinsLipid BilayersMembrane ProteinsPhospholambanRecombinant ProteinsSarcoplasmic Reticulum Calcium-Transporting ATPasesCa2+ regulationConformational equilibriumDilated cardiomyopathyPhospholambanSERCASolid-state NMR

Identifiers

PMID29501609
PMCPMC6428084
OpenAlexW2790438204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.