ArticleNeuroImage2018
Characterization of the hemodynamic response function across the majority of human cerebral cortex.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Pooled it
- Revisiting the auditory hemodynamic response function in the era of fast fMRI.bioRxiv : the preprint server for biology · 2026Article
- Combined Action Observation and Motor Imagery Elicits Superior Frontoparietal Activation in Elite Ski Jumpers: An fNIRS Study.Brain sciences · 2026Article
- Neurovascular Uncoupling in Alzheimer's and Parkinson's Diseases: Mechanisms and Therapeutic Strategies.Brain sciences · 2026Review
- Probabilistic Cognitive State Modeling (PCSM): Decoding dynamic brain states to derive emergent cognitive processing properties from task fMRI.NeuroImage · 2026Article
- VarCoNet: A Variability-Aware Self-Supervised Framework for Functional Connectome Extraction From Resting-State fMRI.Human brain mapping · 2026Article
- Impact of thermal and physiological denoising on laminar functional connectivity.Scientific reports · 2026Article
- Neural Signatures of Engagement and Event Segmentation during Story Listening in Background Noise.eNeuro · 2026Article
- Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T.Frontiers in neuroscience · 2026Article
- Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex.Frontiers in aging neuroscience · 2026Article
- HRNeurophotonics · 2026Article
- Timing Is Everything: Temporal Dynamics of BOLD Responses to Naturalistic Features in Movie Watching.bioRxiv : the preprint server for biology · 2025Article
- Probabilistic Cognitive State Modeling (PCSM): Decoding Latent Spatiotemporal Dynamics to Reveal Serial-Parallel Processing, Cognitive Demand, and Serial Bottleneck in Task-Based fMRI.bioRxiv : the preprint server for biology · 2025Article
- Towards whole brain mapping of the hemodynamic response function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study.NeuroImage · 2025Article
- Minimum-Phase Property of the Hemodynamic Response Function, and Implications for Granger Causality in fMRI.Human brain mapping · 2025Article
- A ketogenic diet decreases sevoflurane-induced burst suppression in rats.Brain research bulletin · 2025Article
- Revealing the Spatial Pattern of Brain Hemodynamic Sensitivity to Healthy Aging through Sparse Dynamic Causal Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Randomization-Based, Model-Free Approach to Functional Neuroimaging: A Proof of Concept.Entropy (Basel, Switzerland) · 2024Article
- Macroscopic resting-state brain dynamics are best described by linear models.Nature biomedical engineering · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A brief (<4 s) period of neural activation evokes a stereotypical sequence of vascular and metabolic events to create the hemodynamic response function (HRF) measured using functional magnetic resonance imaging (fMRI). Linear analysis of fMRI data requires that the HRF be treated as an impulse response, so the character and temporal stability of the HRF are critical issues. Here, a simple audiovisual stimulus combined with a fast-paced task was used to evoke a strong HRF across a majority, ∼77%, of cortex during a single scanning session. High spatiotemporal resolution (2-mm voxels, 1.25-s acquisition time) was used to focus HRF measurements specifically on the gray matter for whole brain. The majority of activated cortex responds with positive HRFs, while ∼27% responds with negative (inverted) HRFs. Spatial patterns of the HRF response amplitudes were found to be similar across subjects. Timing of the initial positive lobe of the HRF was relatively stable across the cortical surface with a mean of 6.1 ± 0.6 s across subjects, yet small but significant timing variations were also evident in specific regions of cortex. The results provide guidance for linear analysis of fMRI data. More importantly, this method provides a means to quantify neurovascular function across most of the brain, with potential clinical utility for the diagnosis of brain pathologies such as traumatic brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.