ArticleNeuropharmacology2018
Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.
Abstract readComparative Study
In one paragraph
Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents.Molecular psychiatry · 2026Article
- Pharmacodynamic effects and plasma pharmacokinetics of N, N-dimethyltryptamine after intranasal versus subcutaneous administration in male rats.Psychopharmacology · 2026Article
- The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects.Molecular psychiatry · 2026Article
- Toxicodynamic insights of 2C and NBOMe drugs - Is there abuse potential?Toxicology reports · 2025Review
- Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.Behavioural pharmacology · 2025Article
- Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs ImpactInternational journal of molecular sciences · 2025Article
- Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice.International journal of molecular sciences · 2025Article
- Chemical Reactivity Parameters to Analyze Psychedelics: How Do We Explain the Potency of the Drugs?ACS omega · 2024Article
- The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents.Archives of pharmacal research · 2024Article
- Psychedelic-like Activity of Norpsilocin Analogues.ACS chemical neuroscience · 2024Article
- Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-ACS pharmacology & translational science · 2023Article
- Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats-pharmacokinetics, effects on behaviour and thermoregulation.Frontiers in pharmacology · 2023Article
- Structure-Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice.ACS pharmacology & translational science · 2022Article
- Automated Computer Software Assessment of 5-Hydroxytryptamine 2A Receptor-Mediated Head Twitch Responses from Video Recordings of Mice.ACS pharmacology & translational science · 2022Article
- Effect ofFrontiers in psychiatry · 2022Article
- Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe.Psychopharmacology · 2021Article
- Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.Molecules (Basel, Switzerland) · 2021Review
- Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore.ACS pharmacology & translational science · 2021Article
- Neurochemical and Behavioral Effects of a New Hallucinogenic Compound 25B-NBOMe in Rats.Neurotoxicity research · 2021Article
- New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents.Archives of toxicology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Joshua S ElmoreDesigner Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.
Ann M DeckerCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC, 27709, USA.
Agnieszka SulimaDrug Design and Synthesis Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, 20892, USA.
Kenner C RiceDrug Design and Synthesis Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, 20892, USA.
John S PartillaDesigner Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.
Bruce E BloughCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC, 27709, USA.
Michael H BaumannDesigner Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA. Electronic address: mbaumann@mail.nih.gov.
National Institute on Drug Abuse · USNational Institutes of Health · USRTI International · US
Funding
Studies on MDMA and Related CompoundsZIADA000523 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI BAUMANN, MICHAEL · 2009 to 2025
$16.4MMedicinal Chemistry of Drugs Acting on Biogenic Amine ReceptorsZIADA000532 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI RICE, KENNER · 2009 to 2020
$4.5MIMPROVING HEALTH CARE UTILIZATION IN HIV+ DRUG USERSK23DA000523 · NIDA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2001 to 2005
$794kIntramural NIH HHS ZIA DA000523NIDA NIH HHS K23 DA000523NULL ZIA DA000523-09
Abstract
2,5-Dimethoxyphenethylamines (2C compounds) are 5-HT
Indexed as
AnimalsBack MusclesBenzylaminesBrainDimethoxyphenylethylamineDose-Response Relationship, DrugFluorobenzenesHallucinogensHead MovementsHEK293 CellsHumansMaleMolecular StructureMotor ActivityMuscle ContractionPhenethylamines2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamineBenzylaminesDimethoxyphenylethylamineFluorobenzenesHallucinogensPhenethylaminesPiperidinesReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin Agentsvolinanserin5-HT(2A) receptorBack muscle contractionsNBOMeWet dog shakes
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.