Trial reportDisability and health journal2018
Changes in cognitive function after a 12-week exercise intervention in adults with Down syndrome.
Trial report in Disability and health journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Virtual Low-Tempo and High-Tempo Zumba® in Individuals With Developmental Disabilities on Functional Mobility, Aerobic Capacity, Inhibitory Control, Attention, and Balance
Group-based Resistance Training for Adults With Down Syndrome; a Feasibility Pilot Randomised Control Crossover Trial
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis and systematic review of interventions to prevent or treat cognitive decline related to Alzheimer's disease in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- The effect of exercise on improving cognitive function in people with Down's syndrome: a systematic review and meta-analysis.European journal of pediatrics · 2025Pooled it
- Effects of Resistance Training in Muscle Mass and Markers of Muscle Damage in Adults with Down Syndrome.International journal of environmental research and public health · 2021Trial
- A Short-Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome.Oxidative medicine and cellular longevity · 2021Trial
- Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention.NeuroSci · 2026Review
- The effect of badminton training on the attention and motor skills performance of integrated students: a study including children with specific learning disorders (SLD).BMC sports science, medicine & rehabilitation · 2026Article
- Systematic multi-omic deconvolution of the clinical heterogeneity of Down syndrome.Nature communications · 2026Article
- Lifestyle intervention and cognitive outcomes in Down syndrome: a horizon 21 European Down syndrome consortium scoping review.Journal of neurodevelopmental disorders · 2026Article
- Aerobic Training for Obesity Management in Individuals with Down Syndrome: A Bibliometric and Meta-Analyses.Healthcare (Basel, Switzerland) · 2026Review
- Pilot evaluation of a dance-based physical activity program for adults with Down syndrome.Translational journal of the American College of Sports Medicine · 2026Article
- Effects of Life Kinetik-based exercise training on cognitive and motor performance in individuals with intellectual disabilities.Frontiers in public health · 2026Article
- Article
- Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2025Article
- Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Successful Online Exercise Intervention Studies for Individuals With Intellectual Disabilities Including Down Syndrome: Best Practices and Recommendations.Journal of applied research in intellectual disabilities : JARID · 2025Article
- The adaptation of the GameSquad exergaming intervention for young adults with Down syndrome: A pilot feasibility study.Disability and health journal · 2025Article
- Brain outcomes with lifestyle change in adults with Down syndrome: Rationale and design for a 12-month randomized trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cerebral oxygenation during submaximal and peak exercise for sedentary adults with and without down syndrome.Frontiers in physiology · 2025Article
- Physical Activity and Cognitive Impairment in a Group of Adults with Down Syndrome from North-Eastern Romania.Journal of clinical medicine · 2024Article
- Effects of chronic aerobic exercise on attentional bias among women with methamphetamine addiction.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundBetween 250,000 and 400,000 individuals in the United States are diagnosed with Down syndrome (DS). Nearly all adults with DS will develop Alzheimer's disease pathology starting in their thirties. Recent studies suggest that increased physical activity (PA) may be important for maintaining components of cognition, including memory.
objectiveThe purpose of this study was to evaluate changes in cognitive function after completion of a 12-week exercise intervention in adults with DS.
methodsParticipants were randomized to attend 30-minute group exercise sessions 1 or 2 times a week for 12 weeks. The exercise sessions were delivered via video conferencing on a tablet computer to groups of 5-8 participants. Sessions consisted of aerobic based exercises such as walking and jogging to music, dancing, as well as strength based exercises such as vertical jumps, bicep curls, and squats. Cognitive function was measured at baseline and end of study using the Cantab Dementia Battery for iPads, which assessed the cognitive domains of memory, attention, and reaction time.
resultsTwenty-seven participants (27.9 ± 7.1 years of age, 40.7% female) enrolled and completed the 12-week intervention. Participants randomized to 1 session/week averaged 26.6 ± 3.0 min/week of PA from the group exercise session. Participants randomized to 2 sessions/week averaged 57.7 ± 15.3 min/week of PA from the group exercise sessions. Participants improved their performance on the two memory variables (p = 0.048 and p = 0.069).
conclusionIncreased exercise may have positive changes on memory and other cognitive functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.