Evidence map›Paper›PMID 29501420›Full record

ArticleExperimental neurology2018

C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2.

Qingyi Ma, Lubo Zhang

Open access · greenAbstract read
In one paragraph

Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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  12. The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester"Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qingyi MaThe Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. Electronic address: qma@llu.edu.
Lubo ZhangThe Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Loma Linda University · US

Funding

Developmental Programming of Ischemic-Sensitive Phenotype in the HeartR01HL118861 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2014 to 2017
$1.8M
MicroRNA 210 and Perinatal Hypoxic-Ischemic Brain InjuryR21NS103017 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2017 to 2018
$435k
NHLBI NIH HHS R01 HL118861NINDS NIH HHS R21 NS103017
6 · The paper itself

Abstract

Neonatal hypoxia-ischemia (HI) is the most common cause of brain injury in neonates, which leads to high neonatal mortality and severe neurological morbidity in later life (Vannucci, 2000; Volpe, 2001). Yet the molecular mechanisms of neuronal death and brain damage induced by neonatal HI remain largely elusive. Herein, using both in vivo and in vitro models, we determine an endogenous neuroprotectant role of c-type natriuretic peptide (CNP) in preserving neuronal survival after HI brain injury in mouse pups. Postnatal day 7 (P7) mouse pups with CNP deficiency (Nppc

Indexed as

AnimalsAnimals, NewbornAtrial Natriuretic Factor Receptor BHypoxia-Ischemia, BrainMiceMice, Inbred C57BLNatriuretic Peptide, C-TypeNeuroprotectionReceptors, Atrial Natriuretic FactorAtrial Natriuretic Factor Receptor BNatriuretic Peptide, C-TypeReceptors, Atrial Natriuretic FactorC-type natriuretic peptideNatriuretic peptide receptor 2Neonatal hypoxic-ischemic brain injuryNeuronal deathOxygen-glucose deprivation

Identifiers

PMID29501420
PMCPMC6087427
OpenAlexW2792524757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.