Evidence map›Paper›PMID 29501382›Full record

ArticleExperimental eye research2018

Expression, regulation and function of miR-126 in the mouse choroid vasculature.

Fangkun Zhao, Chastain Anderson, Sara Karnes, Qinbo Zhou, Jing Ma, Zheng-Gen Jin, Partha S Bhattacharjee, Shusheng Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. MicroRNA-126 as an endogenous molecule for hypoxic/ischemic tolerance in neuroprotection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. MicroRNAs in Vascular Eye Diseases.International journal of molecular sciences · 2020
    Review
  7. [Optical coherence tomography angiography as a future diagnostic tool in sports medicine?]Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Fangkun ZhaoDepartment of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, China; Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Chastain AndersonDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Sara KarnesDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Qinbo ZhouDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Jing MaDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Zheng-Gen JinAab Cardiovascular Research Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box CVRI, Rochester, NY 14620, USA.
Partha S BhattacharjeeDepartment of Biology, Xavier University, New Orleans, LA 70125, USA.
Shusheng WangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA; Department of Ophthalmology, Tulane University, New Orleans, LA 70112, USA. Electronic address: swang1@tulane.edu.
Tulane University · USUniversity of Rochester Medical Center · USXavier University · US

Funding

Regulation of Ocular Angiogenesis by microRNAsR01EY021862 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, SHUSHENG · 2011 to 2021
$2.8M
Role of long noncoding RNAs in human ocular angiogenesisR01EY026069 · NEI · TULANE UNIVERSITY OF LOUISIANA · PI WANG, SHUSHENG · 2016 to 2020
$1.9M
Regulation of angiogenesis by transcription factorsR01HL128363 · NHLBI · UNIVERSITY OF ROCHESTER · PI JIN, ZHENG-GEN · 2016 to 2019
$1.5M
NEI NIH HHS R01 EY021862NEI NIH HHS R01 EY026069NHLBI NIH HHS R01 HL128363
6 · The paper itself

Abstract

MicroRNA miR-126 has been shown to be required for proper angiogenesis in several models. However, its expression, regulation and function in the mouse choroid remain unclear. Our previous data has shown that miR-126 expression is enriched in the endothelial cells (ECs) of the mouse choroid. Here we report that a 5.5 kb Egfl7/miR-126 promoter drives the expression of miR-126 in the choroid ECs during choroidal vascular development. The expression of miR-126 in the ECs is regulated by flow stress likely through Krüppel-like transcriptional factors. miR-126

Indexed as

AnimalsCalcium-Binding ProteinsCells, CulturedChoroidEGF Family of ProteinsEndothelial CellsFluorescein AngiographyGene Expression Regulation, DevelopmentalHumansHuman Umbilical Vein Endothelial CellsMiceMice, Inbred C57BLMice, KnockoutMicroRNAsNeovascularization, PhysiologicPlasmidsCalcium-Binding ProteinsEGF Family of ProteinsEgfl7 protein, mouseMicroRNAsMIRN126 microRNA, mouseProteinsChoroidEndothelial cellsmiR-126Vascular development

Identifiers

PMID29501382
PMCPMC5993209
OpenAlexW2789713803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.