Evidence map›Paper›PMID 29500717›Full record

ArticleEJNMMI research2018

Imaging Aβ and tau in early stage Alzheimer's disease with [

Azadeh Firouzian, Alex Whittington, Graham E Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone, Roger N Gunn, Deep and Frequent Phenotyping study team

Abstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Spatially constrained kinetic modeling with dual reference tissues improvesEuropean journal of nuclear medicine and molecular imaging · 2021
    Article
  6. Clinical validity of increased cortical uptake of [European journal of nuclear medicine and molecular imaging · 2021
    Review
  7. Article
  8. When Does Alzheimer's Disease Really Start? The Role of Biomarkers.International journal of molecular sciences · 2019
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Azadeh FirouzianImanova Ltd., Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK. Azadeh.Firouzian@imanova.co.uk.ORCID http://orcid.org/0000-0001-5424-0489
Alex WhittingtonDepartment of Medicine, Faculty of Medicine, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Graham E SearleImanova Ltd., Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Ivan KoychevDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Giovanna ZamboniNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
Simon LovestoneDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Roger N GunnImanova Ltd., Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Deep and Frequent Phenotyping study team

Funding

Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/N029941/1
6 · The paper itself

Abstract

backgroundAD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate the optimal acquisition and quantification of [

resultsBoth the SRTM and graphical analysis methods showed a good fit to the dynamic data for both Aβ and tau dynamic PET scans. Mean regional BP

conclusionsShort static PET scans at appropriate time windows provided SUVR values which were in reasonable agreement with BP

Indexed as

Alzheimer’s diseaseAmyloidModellingPETTau

Identifiers

PMID29500717
PMCPMC5834417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.