Evidence map›Paper›PMID 29500404›Full record

Observational studySpinal cord2018

Comparison of diurnal blood pressure and urine production between people with and without chronic spinal cord injury.

Min Yin Goh, Melinda S Millard, Edmund C K Wong, David J Berlowitz, Marnie Graco, Rachel M Schembri, Douglas J Brown, Albert G Frauman, Christopher J O'Callaghan

Open access · bronzeAbstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Min Yin GohDepartment of Clinical Pharmacology, Austin Hospital, Heidelberg, VIC, Australia. Min.Goh@austin.org.au.
Melinda S MillardDepartment of Clinical Pharmacology, Austin Hospital, Heidelberg, VIC, Australia.
Edmund C K WongDepartment of Clinical Pharmacology, Austin Hospital, Heidelberg, VIC, Australia.
David J BerlowitzDepartment of Medicine, University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-2543-8722
Marnie GracoDepartment of Medicine, University of Melbourne, Parkville, VIC, Australia.
Rachel M SchembriInstitute for Breathing and Sleep, Austin Hospital, Heidelberg, VIC, Australia.
Douglas J BrownThe Spinal Research Institute, Kew, VIC, Australia.
Albert G FraumanDepartment of Clinical Pharmacology, Austin Hospital, Heidelberg, VIC, Australia.
Christopher J O'CallaghanDepartment of Clinical Pharmacology, Austin Hospital, Heidelberg, VIC, Australia.
The University of Melbourne · AUAustin Hospital · AUAustralian Spinal Research Foundation · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designObservational study.

objectivesTo quantify diurnal blood pressure (BP) patterns and nocturnal hypertension and to measure diurnal urine production in people with chronic spinal cord injury (SCI), compared with controls without SCI.

settingChronic SCI population in the community in Victoria, Australia.

methodsParticipants were recruited by advertisement, and sustained SCI at least a year prior or were healthy able-bodied volunteers. Participants underwent ambulatory BP monitoring (ABPM), measurement of urine production, and completed questionnaires regarding orthostatic symptoms. Comparisons were made between participants with tetraplegia or paraplegia and able-bodied controls. Participants with night:day systolic BP < 90% were classified as dippers, 90-100% as nondippers, and >100% as reverse dippers.

resultsGroups with tetraplegia (n = 51) and paraplegia (n = 33) were older (42.1 ± 15 and 41.1 ± 15 vs. 32.4 ± 13 years, mean ± s.d.) and had a higher prevalence of males (88 and 85% vs. 60%) than controls (n = 52). The average BP was 110.8 ± 1.5/64.4 ± 1.2 mmHg, 119.4 ± 2.1/69.8 ± 1.5 mmHg, and 118.1 ± 1.4/69.8 ± 1.0 mmHg in tetraplegia, paraplegia, and controls, respectively. Of participants with tetraplegia, paraplegia and controls, reverse dipping was observed in 45, 13, and 2% (p < 0.001), while nocturnal hypertension was observed in 13, 23, and 18%, respectively (p = 0.48). A reduction in nocturnal urine flow rate compared with the day was observed in paraplegia and controls, but not tetraplegia.

conclusionsSimilar to the effects of acute SCI, chronic SCI, specifically tetraplegia, also causes isolated nocturnal hypertension, reverse dipping, orthostatic intolerance, and nocturnal polyuria. Cardiovascular risk management and assessment of orthostatic symptoms should include ABPM.

Indexed as

Blood PressureCircadian RhythmUrinationAdolescentAdultAgedBlood Pressure Monitoring, AmbulatoryChronic DiseaseFemaleHeart RateHumansHypertensionMaleMiddle AgedParaplegiaPosture

Identifiers

PMID29500404
OpenAlexW2790527496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.