Evidence map›Paper›PMID 29500353›Full record

ArticleNature communications2018

A mechanism for CO regulation of ion channels.

Sofia M Kapetanaki, Mark J Burton, Jaswir Basran, Chiasa Uragami, Peter C E Moody, John S Mitcheson, Ralf Schmid, Noel W Davies, Pierre Dorlet, Marten H Vos and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

  1. An extended network for regulation of heme homeostasis in cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Carbon Monoxide and Prokaryotic Energy Metabolism.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Regulation of protein function and degradation by heme, heme responsive motifs, and CO.Critical reviews in biochemistry and molecular biology · 2022
    Review
  12. Early processes in heme-based CO-sensing proteins.Frontiers in molecular biosciences · 2022
    Review
  13. Review
  14. Enzyme-activated probes in optical imaging: a focus on atherosclerosis.Dalton transactions (Cambridge, England : 2003) · 2021
    Review
  15. Review
  16. A Coumarin-Porphyrin FRET Break-Apart Probe for Heme Oxygenase-1.Journal of the American Chemical Society · 2021
    Article
  17. Carbon monoxide activates large-conductance calcium-activated potassium channels of human cardiac fibroblasts through various mechanisms.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Sofia M KapetanakiDepartment of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, England.
Mark J BurtonDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England.
Jaswir BasranDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England.
Chiasa UragamiInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette cedex, France.
Peter C E MoodyDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England.ORCID http://orcid.org/0000-0003-1762-9238
John S MitchesonDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England.
Ralf SchmidDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England.
Noel W DaviesDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England.
Pierre DorletInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette cedex, France.ORCID http://orcid.org/0000-0001-7394-3374
Marten H VosLOB, Ecole Polytechnique, CNRS, INSERM, Université Paris-Saclay, 91128, Palaiseau Cedex, France.ORCID http://orcid.org/0000-0003-0493-4831
Nina M StoreyDepartment of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 9HN, England. ns140@le.ac.uk.
Emma RavenDepartment of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, England. emma.raven@le.ac.uk.ORCID http://orcid.org/0000-0002-1643-8694
University of Leicester · GBUniversité Paris-Sud · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite being highly toxic, carbon monoxide (CO) is also an essential intracellular signalling molecule. The mechanisms of CO-dependent cell signalling are poorly defined, but are likely to involve interactions with heme proteins. One such role for CO is in ion channel regulation. Here, we examine the interaction of CO with K

Indexed as

Amino Acid MotifsAmino Acid SequenceCarbon MonoxideHEK293 CellsHemeHumansIon Channel GatingIon ChannelsKATP ChannelsModels, MolecularSpectrum Analysis, RamanSulfonylurea ReceptorsABCC9 protein, humanCarbon MonoxideHemeIon ChannelsKATP ChannelsSulfonylurea Receptors

Identifiers

PMID29500353
PMCPMC5834611
OpenAlexW2799575491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.