ArticleNature communications2018
Strong selection during the last millennium for African ancestry in the admixed population of Madagascar.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman.American journal of human genetics · 2026Article
- Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic evidence supports the "long chronology" for the peopling of Sahul.Science advances · 2025Article
- Tracing human genetic histories and natural selection with precise local ancestry inference.Nature communications · 2025Article
- Characterization of the phenotypic consequences of the Duffy-null genotype.Blood advances · 2025Article
- Inferring multi-locus selection in admixed populations.PLoS genetics · 2023Article
- Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism.Pharmacogenomics · 2023Article
- Localizing Post-Admixture Adaptive Variants with Object Detection on Ancestry-Painted Chromosomes.Molecular biology and evolution · 2023Article
- Identifying Genomic Signatures of Positive Selection to Predict Protective Genomic Loci in the Cohort of Lithuanian Clean-Up Workers of the Chornobyl Nuclear Disaster.Current issues in molecular biology · 2023Article
- Modern Japanese ancestry-derived variants reveal the formation process of the current Japanese regional gradations.iScience · 2023Article
- Article
- Single nucleotide variants in microRNA biosynthesis genes in Mexican individuals.Frontiers in genetics · 2023Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Disentangling Signatures of Selection Before and After European Colonization in Latin Americans.Molecular biology and evolution · 2022Article
- The genomic signatures of natural selection in admixed human populations.American journal of human genetics · 2022Article
- Article
- Review
- The Peopling and Migration History of the Natives in Peninsular Malaysia and Borneo: A Glimpse on the Studies Over the Past 100 years.Frontiers in genetics · 2022Review
- African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations.Brain sciences · 2021Article
- New insights into human immunity from ancient genomics.Current opinion in immunology · 2021Review
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Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history.
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