Evidence map›Paper›PMID 29500330›Full record

ArticleAging2018

Do senescence markers correlate in vitro and in situ within individual human donors?

Mariëtte E C Waaijer, David A Gunn, Diana van Heemst, P Eline Slagboom, John M Sedivy, Roeland W Dirks, Hans J Tanke, Rudi G J Westendorp, Andrea B Maier

Open access · greenAbstract readComparative Study
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Skin Aging, Cellular Senescence and Natural Polyphenols.International journal of molecular sciences · 2021
    Review
  7. Cellular Senescence and Inflammaging in the Skin Microenvironment.International journal of molecular sciences · 2021
    Review
  8. Article
  9. LncRNAs Regulatory Networks in Cellular Senescence.International journal of molecular sciences · 2019
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Mariëtte E C WaaijerDepartment of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
David A GunnUnilever Discover, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Diana van HeemstDepartment of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
P Eline SlagboomNetherlands Consortium for Healthy Aging, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
John M SedivyDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
Roeland W DirksDepartment of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Hans J TankeDepartment of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Rudi G J WestendorpDepartment of Public Health and Center for Healthy Aging, Faculty of Health and Medical Sciences, 1123 Copenhagen, Denmark.
Andrea B MaierMOVE Research Institute Amsterdam, Department of Human Movement Sciences, VU University of Amsterdam, 1007 MB Amsterdam, The Netherlands.
Leiden University Medical Center · NLNetherlands Consortium for Healthy Ageing · NLBrown University · USCapital Region of Denmark · DKUnilever (United Kingdom) · GBUniversity of Amsterdam · NL

Funding

Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI Jef D BOEKE · 2016 to 2026
$30.4M
MECHANISMS OF REPLICATIVE SENESCENCE IN CELLSR01AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 1999 to 2024
$5.7M
Effectors of cellular senescence statesR37AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 2009 to 2018
$3.2M
NIA NIH HHS P01 AG051449NIA NIH HHS R37 AG016694
6 · The paper itself

Abstract

Little is known on how well senescence markers

Indexed as

AdultAgedAged, 80 and overbeta-GalactosidaseBiomarkersCells, CulturedCellular SenescenceFemaleFibroblastsGenes, p16HumansMaleMiddle AgedReactive Oxygen SpeciesTelomereYoung Adultbeta-GalactosidaseBiomarkersReactive Oxygen Speciescellular senescencecorrelationin situin vitromarkers

Identifiers

PMID29500330
PMCPMC5842854
OpenAlexW2789509317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.