ArticleScience immunology2018
RORα-expressing T regulatory cells restrain allergic skin inflammation.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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79citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 119 citations in OpenAlex.
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026Review
- From Barrier Disruption and Immune Dysregulation to Targeted Therapies in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2026Review
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- CAR Treg therapies for neurodegenerative diseases.iScience · 2026Review
- Exploring the relative contribution of genetic and external exposomic risk scores to allergies in elderly women.Scientific reports · 2026Article
- TL1A morphological shifts and inflammatory heterogeneity in rhinosinusitis and allergic rhinitis: a hypothesis-driven review.Frontiers in immunology · 2026Review
- Review
- Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue.Cell host & microbe · 2025Article
- Understanding Atherosclerotic Plaque Cellular Composition: Recent Advances Driven by Single Cell Omics.Cells · 2025Review
- Unspoken words: decoding the dialog between type 2 innate lymphoid cells and T cells.Frontiers in immunology · 2025Review
- Autism spectrum disorder and the role of nuclear hormone receptors: insights and therapeutic implications.Frontiers in neuroscience · 2025Review
- The immunobiology and therapeutic potential of regulatory T cells in autoimmune diseases and allergic diseases.Frontiers in immunology · 2025Review
- Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications.Frontiers in immunology · 2025Review
- Regulatory T cells and their role in allergic disease.Allergy · 2025Review
- Epithelial-immune interactions govern type 2 immunity at barrier surfaces.Current opinion in immunology · 2024Review
- TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation.The Journal of experimental medicine · 2024Article
- Regulatory T cells in dominant immunologic tolerance.The Journal of allergy and clinical immunology · 2024Review
- Group 2 Innate Lymphoid Cells in Allergic Rhinitis.Journal of inflammation research · 2024Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Nidhi MalhotraDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. nidhi.malhotra@elstartherapeutics.com manuel.leyvacastillo@childrens.harvard.edu raif.geha@childrens.harvard.edu.ORCID 0000-0001-8262-9686
Juan Manuel Leyva-CastilloDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. nidhi.malhotra@elstartherapeutics.com manuel.leyvacastillo@childrens.harvard.edu raif.geha@childrens.harvard.edu.ORCID 0000-0001-7394-4457
Unmesh JadhavDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Olga BarreiroDepartment of Microbiology and Immunobiology and Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA.
Christy KamDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8834-4929
Nicholas K O'NeillDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0002-9953-9940
Francoise MeylanImmunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9279-7875
Pierre ChambonInstitut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS UMR7104, INSERM U964), Illkirch 67404, France.ORCID 0000-0002-7861-6046
Ulrich H von AndrianDepartment of Microbiology and Immunobiology and Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA.
Richard M SiegelImmunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Eddie C WangDepartment of Microbial Microbiology and Infectious Diseases, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-2243-4964
Ramesh ShivdasaniDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0002-2828-1727
Raif S GehaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. nidhi.malhotra@elstartherapeutics.com manuel.leyvacastillo@childrens.harvard.edu raif.geha@childrens.harvard.edu.ORCID 0000-0001-8262-9686
Harvard University · USBoston Children's Hospital · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USCardiff University · GBCentre National de la Recherche Scientifique · FR
Funding
Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI GEHA, RAIF SALIM · 2015 to 2019
$30.6MSEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0MThe Next Generation Immunoanalysis CoreP30AR069625 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN · 2016 to 2025
$8.8MMechanisms of food allergy elicited by cutaneous sensitizationR01AI113294 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GEHA, RAIF SALIM · 2016 to 2019
$2.1MMedical Research Council G0901119NIAID NIH HHS HHSN272201000020CNIAID NIH HHS R01 AI113294NIAID NIH HHS U01 AI147462NIAID NIH HHS U19 AI117673NIAMS NIH HHS P30 AR069625
Abstract
Atopic dermatitis is an allergic inflammatory skin disease characterized by the production of the type 2 cytokines in the skin by type 2 innate lymphoid cells (ILC2s) and T helper 2 (T
Indexed as
AnimalsDermatitis, AtopicFemaleHumansImmunity, InnateMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 1Receptors, Tumor Necrosis Factor, Member 25SkinT-Lymphocytes, RegulatoryTumor Necrosis Factor Ligand Superfamily Member 15Nuclear Receptor Subfamily 1, Group F, Member 1Receptors, Tumor Necrosis Factor, Member 25Tumor Necrosis Factor Ligand Superfamily Member 15
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.