ArticleBiomedical engineering online2018
Influence of vascular geometry on local hemodynamic parameters: phantom and small rodent study.
Article in Biomedical engineering online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation.Cardiovascular engineering and technology · 2020Pooled it
- A comparative study between CT angiography and flow parameters in hemodynamic phantom of carotid stenosis evaluated by duplex sonography.3D printing in medicine · 2025Article
- The Stress Phase Angle Measurement Using Spectral Domain Optical Coherence Tomography.Sensors (Basel, Switzerland) · 2023Article
- Age- and gender-dependent variability in the geometry of middle cerebral artery bifurcations.Journal of anatomy · 2021Article
- Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes.Nature protocols · 2021Article
- Semi-automatic measurements and description of the geometry of vascular tree based on Bézier spline curves: application to cerebral arteries.Biomedical engineering online · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMany studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wall circumferential strain and its instantaneous wall shear stress is known as stress phase angle (SPA). This parameter is used to evaluate hemodynamic factors of atherogenesis. Note that SPA can be numerically computed for the purpose of locating atherosclerosis in different artery geometries. However, there is no experimental data to verify its role in the location of atherosclerosis in different artery geometries. In this study, we use an ultrasonic biomechanical method to experimentally evaluate the role of SPA for locating atherosclerosis in carotid bifurcation.
resultsFor carotid anthropomorphic vascular phantom experiments, the SPAs of common carotid arteries (CCAs), external carotid arteries (ECAs) and internal carotid arteries (ICAs) are - 148.53 ± 6.92°, - 153.95 ± 5.11°, and - 238.69 ± 1.72°, respectively. The corresponding SPAs are - 173.47 ± 0.065°, - 115.57 ± 4.83° and - 233.9 ± 8.12° for the polyvinyl alcohol (PVA-c) phantoms. In vivo mouse experiments indicated that the wall shear stress and circumferential strain were out of phase in the ICAs (- 280.08 ± 13.12°) to a greater extent as compared to CCAs (- 141.97 ± 8.03°) and ECAs (- 170.07 ± 9.24°).
conclusionsThe results suggested that SPA may be a useful indicator to locate the atherosclerosis position in carotid bifurcation.
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